Negara: Taiwan
Bahasa: China
Sumber: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)
CLOMIPHENE CITRATE
台灣默克股份有限公司 台北市內湖區堤頂大道2段89號6樓 (23526610)
G03GB02
錠劑
CLOMIPHENE CITRATE (6816000110) MG
鋁箔盒裝
製 劑
須由醫師處方使用
TEVA PHARMACEUTICAL INDUSTRIES LTD. 18, ELI HURVITZ STREET, KFAR SABA 44102, ISRAEL IL
clomifene
不排卵婦女之不孕症
註銷日期: 2018/03/13; 註銷理由: 未展延而逾期者; 有效日期: 2016/10/29; 英文品名: SEROPHENE
已註銷
1996-10-29
SEROPHENE® Clomiphene Citrate Tablets (U.S.P./B.P.) DESCRIPTION Each scored white tablet contains: Clomiphene Citrate USP 50 mg Clomiphene citrate is designated chemically as 2‐[p‐(2‐chloro‐1,2‐ diphenylvinyl) phenoxy] triethylamine dihydrogen citrate and is represented structurally as As shown, one molecule of citric acid is chemically bound with one molecule of the organic base, clomiphene. Clomiphene citrate is a chemical analogue of other triarylethylene compounds such as chlorotrianisene and the cholesterol inhibitor, triparanol. Excipient : Microcrystalline Cellulose, Colloidal Silicon Dioxide, Magnesium Stearate, Sodium Starch Glycolate, Lactose Monohydrate, Starch ACTIONS Clomiphene citrate, an orally‐administered, non‐steroidal agent, may induce ovulation in selected anovulatory women. It is a drug of considerable pharmacologic potency. Careful evaluation and selection of the patient and close attention to the timing of the dose is mandatory prior to treatment with clomiphene citrate. Conservative selection and management of the patient contribute to successful therapy of anovulation. Clomiphene citrate induces ovulation in most selected anovulatory patients. The various criteria for ovulation include: an ovulation peak of estrogen excretion followed by a biphasic basal body temperature curve; urinary excretion of pregnanediol at postovulatory levels and, endometrial histologic findings characteristic of the luteal phase. A review of eleven publications appearing between 1964 and 1978 showed that pregnancy occurred in 35% of 5154 patients with ovulatory dysfunction who received clomiphene citrate. PREGNANCIES FOLLOWING CLOMIPHENE CITRATE A Number of Patients = 5154 (Range) Percent of Patients Ovulating b = 75 (50‐94)% Percent of Ovulatory Cycles = 53 (33‐69)% Percent of Patients Pregnant = 35 (11‐52)% Percent Patients Pregnant Percent Patients Ovulating = 46 (22‐61)% Percent Live Birth = 86 (74‐99.8)% Percent Abortions = 14 (0.2‐26)% Percent of Single Births = 90 (67‐100)% Baca dokumen lengkapnya