Country: Ամերիկայի Միացյալ Նահանգներ
language: անգլերեն
source: NLM (National Library of Medicine)
TILETAMINE HYDROCHLORIDE (UNII: 99TAQ2QWJI) (TILETAMINE - UNII:2YFC543249), ZOLAZEPAM HYDROCHLORIDE (UNII: 45SJ093Q1N) (ZOLAZEPAM - UNII:G1R474U58U)
Jurox Pty. Limited
INTRAMUSCULAR
PRESCRIPTION
Dogs Zoletil for Injection is indicated in dogs for restraint and minor procedures of short duration (30 min. avg.) requiring mild to moderate analgesia. Minor surgery is considered to be a laceration repair, draining of abscesses, castrations and other procedures requiring mild to moderate analgesia. (See Dogs under Dosage and Administration.) Cats Zoletil for Injection is indicated in cats for restraint or for anesthesia combined with muscle relaxation. The use of Zoletil for Injection is contraindicated in dogs and cats with pancreatic disease. Zoletil for Injection should not be used in dogs and cats with severe cardiac or pulmonary dysfunction. Because the teratogenic potential of Zoletil for Injection is unknown, it should not be used in pregnant bitches or queens at any stage of pregnancy. Also, a study has shown that tiletamine and zolazepam injection crosses the placental barrier and produces respiratory depression in the newborn; therefore, its use for Cesarean section is contraindicated.
Zoletil for Injection (tiletamine and zolazepam for injection) is available in individual vials of 5 mL solution when reconstituted. The addition of 5 mL diluent produces a solution containing the equivalent of 50 mg tiletamine base, 50 mg zolazepam base and 57.7 mg mannitol per milliliter. 5 mL vial – 100 mg/mL total (equivalent to 50 mg/mL tiletamine and 50 mg/mL zolazepam) when reconstituted.
Abbreviated New Animal Drug Application
ZOLETIL- TILETAMINE AND ZOLAZEPAM FOR INJECTION INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION JUROX PTY. LIMITED ---------- ZOLETIL FOR INJECTION (TILETAMINE AND ZOLAZEPAM FOR INJECTION) CIII 100 MG/ML TOTAL (EQUIVALENT TO 50 MG/ML TILETAMINE AND 50 MG/ML ZOLAZEPAM) FOR INTRAMUSCULAR USE IN DOGS AND CATS ONLY CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Zoletil for Injection (tiletamine and zolazepam for injection) is a nonnarcotic, nonbarbiturate, injectable anesthetic agent for dogs and cats. Chemically, Zoletil for Injection is a combination of equal parts by weight of base of tiletamine hydrochloride (2-[ethylamino]-2-[2-thienyl]-cyclohexanone hydrochloride), an arylaminocycloalkanone dissociative anesthetic, and zolazepam hydrochloride (4-[o- fluorophenyl]-6, 8-dihydro-1,3,8- trimethylpyrazolo [3, 4-e] [1,4] diazepin-7 [1H]-1- hydrochloride), a non-phenothiazine diazepinone having minor tranquilizing properties. The product is supplied sterile in vials. The addition of 5 mL diluent produces a solution containing the equivalent of 50 mg tiletamine base, 50 mg zolazepam base and 57.7 mg mannitol per milliliter. This solution has a pH of 2 to 3.5 and is recommended for deep intramuscular injection. INDICATIONS DOGS Zoletil for Injection is indicated in dogs for restraint and minor procedures of short duration (30 min. avg.) requiring mild to moderate analgesia. Minor surgery is considered to be a laceration repair, draining of abscesses, castrations and other procedures requiring mild to moderate analgesia. (See Dogs under Dosage and Administration.) CATS Zoletil for Injection is indicated in cats for restraint or for anesthesia combined with muscle relaxation. DOSAGE AND ADMINISTRATION THE DOSE IS DETERMINED BY THE TOTAL COMBINED CONCENTRATION OF 100 MG/ML (SEE HOW SUPPLIED) DOGS _INTRAMUSCULAR (IM) FOR RESTRAINT AND MINOR PROCEDURES OF SHORT DURATION REQUIRING MILD TO MODERATE_ _ANALGESIA:_ In healthy dogs, an initial intramuscular dosage of 3 to 4.5 read_full_document