Երկիր: Ամերիկայի Միացյալ Նահանգներ
Լեզու: անգլերեն
Աղբյուրը: NLM (National Library of Medicine)
Ketamine Hydrochloride (UNII: O18YUO0I83) (Ketamine - UNII:690G0D6V8H)
VetOne
Ketamine Hydrochloride
Ketamine 100 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION
ZetamineTM (ketamine hydrochloride injection, USP) may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint. Ketamine hydrochloride is contraindicated in cats and subhuman primates suffering from renal or hepatic insufficiency. Ketamine hydrochloride is detoxified by the liver and excreted by the kidneys; therefore, any preexistent hepatic or renal pathology or impairment of function can be expected to result in prolonged anesthesia; related fatalities have been reported.
ZetamineTM (ketamine hydrochloride injection, USP) is supplied as the hydrochloride in concentrations equivalent to ketamine base. Each 10 mL vial contains 100 mg/mL. NDC 13985-702-10 — 10 mL — vial
Abbreviated New Animal Drug Application
ZETAMINE- KETAMINE HYDROCHLORIDE INJECTION, SOLUTION VETONE ---------- VETONE ZETAMINE™ CIII (Ketamine Hydrochloride Injection, USP) For Intramuscular Use in Cats and Subhuman Primates Only CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Ketamine hydrochloride is a rapid-acting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and for restraint in subhuman primates. It is chemically designated DL 2-(o-chlorophenyl) - 2 - (methylamino) cyclohexanone hydrochloride and is supplied as a slightly acid (pH 3.5 to 5.5) solution for intramuscular injection in a concentration containing the equivalent of 100 mg ketamine base per milliliter and contains 0.1 mg/mL benzethonium chloride as a preservative. ACTION: Ketamine hydrochloride is a rapid-acting agent whose pharmacological action is characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, mild cardiac stimulation and respiratory depression. Skeletal muscle tone is variable and may be normal, enhanced or diminished. The anesthetic state produced does not fit into the conventional classification of stages of anesthesia, but instead ketamine hydrochloride produces a state of unconsciousness which has been termed “dissociative” anesthesia in that it appears to selectively interrupt association pathways to the brain before producing somesthetic sensory blockade. In contrast to other anesthetics, protective reflexes, such as coughing and swallowing, are maintained under ketamine hydrochloride anesthesia. The degree of muscle tone is dependent upon level of dose; therefore, variations in body temperature may occur. At low dosage levels there may be an increase in muscle tone and a concomitant slight increase in body temperature. However, at high dosage levels there is some diminution in muscle tone and a resultant decrease in body temperature, to the point where supplemental heat may be advisable. In cats, there is usually some transient cardiovascular stimulation, increased card Կարդացեք ամբողջական փաստաթուղթը