VETRIMEC- ivermectin solution

Country: Ամերիկայի Միացյալ Նահանգներ

language: անգլերեն

source: NLM (National Library of Medicine)

active_ingredient:

Ivermectin (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D)

MAH:

MWI VetOne

INN:

Ivermectin

composition:

Ivermectin 5 mg in 0.001 L

administration_route:

TOPICAL

prescription_type:

OTC

therapeutic_indication:

INDICATIONS VetrimecTM Pour-On (ivermectin topical solution) applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi             (including inhibited stage)                                 (adults and L4) Haemonchus placei          (adults and L4) Trichostrongylus axei         (adults and L4) T. colubriformis  (adults and L4) Cooperia oncophora        (adults and L4) Cooperia punctata (adults and L4) Cooperia surnabada        (adults and L4) Strongyloides papillosus  (adults) Oesophagostomum radiatum (adults and L4) Trichuris spp.      (parasitic stages) Lung Worms Dictyocaulus viviparus    (adults and L4) Cattle Grubs Hypoderma bovis H. lineatum Mites Sarcoptes scabiei  var. bovis Lice Linognathus vituli Haematopinus eurysternus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans PERSISTENT ACTIVITY Ivermectin topical solution has been proved to effectively control infecti

leaflet_short:

HOW SUPPLIED VetrimecTM Pour-On (ivermectin topical solution) is available in a 33.8 fl oz/1 Liter Bottle with a measure-squeeze-pour system, an 84.5 fl oz/2.5 Liter Pack, a 169 fl oz/5 Liter Pack, a 338 fl oz/10 Liter Bottle and a 676 fl oz/20 Liter Bottle intended for use with appropriate automatic dosing equipment.

authorization_status:

Abbreviated New Animal Drug Application

SPC

VETRIMEC- IVERMECTIN SOLUTION
MWI VETONE
----------
VETRIMEC POUR-ON
(IVERMECTIN TOPICAL SOLUTION)
FOR CATTLE
APPROVED BY FDA UNDER ANADA # 200-318
CONTAINS 5 MG IVERMECTIN/ML
PARASITICIDE
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND
CONTROL OF PARASITISM.
INTRODUCTION
Vetrimec
Pour-On (ivermectin topical solution) delivers internal and external
parasite
control in one convenient low-volume application. Vetrimec
Pour-On (ivermectin topical
solution) contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a
unique mode of action. Compounds of the class bind selectively and
with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle
cells. This leads to an increase in the permeability of the cell
membrane to chloride ions
with hyperpolarization of the nerve or muscle cell, resulting in
paralysis and death of the
parasite. Compounds of this class may also interact with other
ligand-gated chloride
channels, such as those gated by the neurotransmitter
gamma-aminobutyric acid
(GABA). The margin of safety for compounds of this class is
attributable to the fact that
mammals do not have the glutamate-gated chloride channels, the
macrocyclic lactones
have a low affinity for other mammalian ligand-gated chloride channels
and they do not
readily cross the blood-brain barrier.
INDICATIONS
Vetrimec
Pour-On (ivermectin topical solution) applied at the recommended dose
level
of 500 mcg/kg is indicated for the effective treatment and control of
these parasites.
GASTROINTESTINAL ROUNDWORMS
_Ostertagia ostertagi_
(including inhibited stage)
(adults and L4)
_Haemonchus placei _
(adults and L4)
_Trichostrongylus axei _
(adults and L4)
_T. colubriformis _
(adults and L4)
_Cooperia oncophora _
(adults and L4)
_Cooperia punctata_
(adults and L4)
_Cooperia surnabada _
(adults and L4)
_Strongyloides papillosus _
(adults)
_Oesophagostomum radiatum_
(adults and L4)
_Trichuris _spp_