Uphamol Menstrual Tablet 50025mg

Country: Մալայզիա

language: անգլերեն

source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

active_ingredient:

Paracetamol; PAMABROM

MAH:

Duopharma Marketing Sdn. Bhd.

INN:

Paracetamol; PAMABROM

units_in_package:

20tablet Tablets; 180tablet Tablets

manufactured_by:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

PIL

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
UPHAMOL MENSTRUAL TABLET
Paracetamol/Pamabrom (500mg /25mg)
WHAT IS IN THE LEAFLET?
1.
What
Uphamol
Menstrual
is
used for
2.
How Uphamol Menstrual works
3.
Before
you
use
Uphamol
Menstrual
4.
How to use Uphamol Menstrual
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
Uphamol Menstrual
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT UPHAMOL MENSTRUAL IS USED
FOR
Uphamol
Menstrual
is
used
for
symptomatic
relief
water-weight
gain,
bloating,
swelling,
headache,
backache, muscular aches, pains and
cramps associated with premenstrual
and menstrual periods.
HOW UPHAMOL MENSTRUAL WORKS
Uphamol
Menstrual
contains
paracetamol and pamabrom as active
ingredients.
Paracetamol
works
by
relieving pain. Pamabrom acts as a
diuretic by increasing urination.
BEFORE
YOU
USE
UPHAMOL
MENSTRUAL
-
_When you must not take it _
_ _
Do
not
take
this
medicine
if
you
have an allergy to:
•
Paracetamol
•
Pamabrom
•
any of the other ingredients listed
at the end of this leaflet
Do not take this medicine if you:
•
have liver failure
•
have problem with urination
•
are
taking
other
products
containing paracetamol
Do not take this medicine after the
expiry date printed on the pack or if
the packaging is torn or shows signs
of tampering. If it has expired or is
damaged,
return
it
to
your
pharmacist for disposal.
-
_Before you start to use it _
_ _
Tell
your
doctor
if
you
have
allergies
to
any
other
medicines,
foods, preservatives or dyes.
Tell your doctor if you have or have
ever had any other health problems /
medical conditions, including:
• liver disease
• kidney disease
-
_Taking other medicines _
_ _
Tell your doctor or pharmacist if you
are
taking
any
other
medicines,
including any that you get without a
prescription
from
your
pharmacy,
supermarket or health food shop.
Some
medicines
and
Uphamol
Menstrual may interfere with each
other. These include:
•
Warfarin
•
Any other diuretic
Your
doctor
and
pharm

SPC

MS2424:2012
1262-09/2004
1500008927 N.1
May 2019
PHARMACODYNAMICS
Analgesic: The mechanism of analgesic action has not been fully
determined. Paracetamol may act predominantly by inhibiting
prostaglandin synthesis in
the central nervous system (CNS) and to lesser extent, through a
peripheral action by blocking pain-impulse generation. The peripheral
action may also be
due to inhibition of prostaglandin synthesis or to inhibition of the
synthesis of action of other substances that sensitize pain receptors.
Antipyretic: Paracetamol probably produces antipyresis by acting
centrally on the hypothalamic heat regulating center to produce
peripheral vasodilation
resulting in increased blood flow through the skin, sweating and heat
loss. The central action probably involves inhibition of prostaglandin
synthesis in the
hypothalamus.
Pamabrom acts as a diuretic by increasing renal blood flow and
glomerular filtration rate thus, promoting diuretics.
PHARMACOKINETICS
Paracetamol is rapidly and almost completely absorbed after oral
administration.
Approximately 90-95% of a dose is metabolized in the liver, primarily
by conjugation with glucoronic acid, sulfuric acid and cysteine. Peak
concentration can
be achieved within 0.5-2 hours. Paracetamol is excreted primarily as
conjugates via the kidney.
SYMPTOMS AND TREATMENT OF OVERDOSE
Early symptoms (nausea, vomiting, and weakness) usually occur after
ingestion of paracetamol overdose large enough to cause hepatic
toxicity.
First empty stomach via induction of emesis or gastric lavage. It is
recommended that acetylcysteine administration be instituted as soon
as possible after
ingestion of an overdose has been reported without waiting for the
results of plasma paracetamol concentration or other laboratory tests.
Acetylcysteine
is most effective if treatment is started within 10 to 12 hours after
ingestion of the overdose. However, it may be of some benefits if
treatment is started
within 24 hours.
For oral administration, the recommended adult dose of acetylcysteine
is 140mg per