TILMICOSIN-LD 250MGML ORAL SOLUTION

Երկիր: Մալայզիա

Լեզու: անգլերեն

Աղբյուրը: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ակտիվ բաղադրիչ:

TILMICOSIN

Հասանելի է:

Kty Chemicals Sdn. Bhd.

INN (Միջազգային անվանումը):

TILMICOSIN

Միավորները փաթեթում:

1 L

Պատրաստված է:

Nam Pharma Sdn. Bhd.

Ապրանքի հատկությունները

Package Inserts
I.
Brand or Product Name:
TILMICOSIN-LD 250MG/ML Oral Solution
II.
Name and Strength of Active Substance:
Tilmicosin, 250mg in 1mL
III.
Product Description:
A brown clear solution.
IV.
Target Species:
Chicken (broilers and pullet), turkeys, pigs and cattle (calves).
V.
Pharmacodynamics:
Tilmicosin is a mainly bactericidal semi-synthetic antibiotic of the
macrolide
group. It is believed to affect bacterial protein synthesis.
Tilmicosin has a wide
spectrum of activity against Gram-positive organisms and is
particularly active
against
Pasteurella,
Actinobacillus
(Haemophilus)
and
Mycoplasma
organisms of bovine, porcine and avian origin. Tilmicosin has some
activity
against certain Gram-negative micro-organisms. Cross resistance
between
tilmicosin and other macrolide antibiotics has been observed.
Macrolides
inhibit protein synthesis by reversibly binding to the 50S ribosomal
subunitl.
Bacterial growth is inhibited by induction of the separation of
peptidyl transfer
RNA from the ribosome during the elongation phase. Ribosomal
methylase,
encoded
by
the
erm
gene,
can
precipitate
resistance
to
macrolides
by
alteration of the ribosomal binding site. The gene that encodes for an
efflux
mechanism,
mef,
also
brings
about
a
moderate
degree
of
resistance.
Resistance is also brought about by an efflux pump that actively rids
the cells
of the macrolide. This efflux pump is chromosomally mediated by genes
referred to as acrAB genes. Resistance of Pseudomonas species and
other
Gramnegative bacteria, enterococci and staphylococci may be
precipitated by
chromosomally controlled alteration of permeability or uptake of the
drug.
VI.
Pharmacokinetics:
When administered orally to chickens, turkeys and pigs with drinking
water
and to calves with milk replacer, tilmicosin is absorbed and moves
rapidly out
of
the
serum
into
areas
of
low
pH.
This
results
in
very
low
serum
concentrations, but detectable levels of tilmicosin are found in lung
tissue as
early as 6 hours after starting the treatment. In chicken or turkeys,
tilm