tepanil- diethylpropion hydrochloride tablet, extended release

Երկիր: Ամերիկայի Միացյալ Նահանգներ

Լեզու: անգլերեն

Աղբյուրը: NLM (National Library of Medicine)

Ակտիվ բաղադրիչ:

diethylpropion hydrochloride (UNII: 19V2PL39NG) (diethylpropion - UNII:Q94YYU22B8)

Հասանելի է:

Qualitest Products, Inc.

INN (Միջազգային անվանումը):

diethylpropion hydrochloride

Դեղագործական ձեւ:

TABLET, EXTENDED RELEASE

Կազմը:

75 mg

Կառավարման երթուղին:

ORAL

Ռեկվիզորի տեսակը:

PRESCRIPTION DRUG

Թերապեւտիկ ցուցումներ:

Diethylpropion hydrochloride tablets are indicated in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regiment of weight reduction based on caloric restriction. The usefulness of agents of this class should be measured against possible risk factors inherent in their use such as those described (see CLINICAL PHARMACOLOGY). Diethylpropion hydrochloride should not be used in patients with advanced arteriosclerosis, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma, severe hypertension, a history of drug abuse, or those in an agitated state (see PRECAUTIONS). Diethylpropion hydrochloride should not be given during, or within fourteen days following, the administration of monoamine oxidase inhibitors; hypertensive crises may result. Diethylpropion is a schedule IV controlled substance. Diethylpropion has some chemical and pharmacologic similarities to the amphetamines and other related stimulant drugs that have been extensively abused.

Ապրանքի ամփոփագիր:

Diethylpropion hydrochloride 75 mg tablets are oval, white, domed, imprinted “2690V” on one side and plain on the other. Diethylpropion hydrochloride 75 mg tablets are supplied in bottles of 100 and 250. Dispense in a tight, light-resistant container as defined in the USP with a child-resistant closure. Store at controlled room temperature, 15°- 30°C (59°- 86°F).

Ապրանքի հատկությունները

TEPANIL- DIETHYLPROPION HYDROCHLORIDE TABLET, EXTENDED RELEASE
QUALITEST PRODUCTS, INC.
----------
TEPANIL TEN-TAB, 75 MG, CONTROLLED RELEASE TABLETS (DIETHYLPROPION
HYDROCHLORIDE)
CIV
DESCRIPTION
Diethylpropion hydrochloride, a sympathomimetic agent. Chemically,
diethylpropion hydrochloride is
1-phenyl-2-diethylamino-1-propanone hydrochloride.
Structural formula: C
H NO HCl
Molecular weight: 241.76
Each tablet contains diethylpropion hydrochloride 75 mg in a
controlled-release formulation.
Diethylpropion hydrochloride tablets also contain: carbomer, mannitol,
povidone, tartaric acid and zinc
stearate.
Diethylpropion hydrochloride is dispersed in a hydrophilic matrix. On
exposure to water the
diethylpropion hydrochloride is released at a relatively uniform rate
as a result of slow hydration of the
matrix. The result is controlled release of the anorexic agent.
CLINICAL PHARMACOLOGY
Diethylpropion hydrochloride is a sympathomimetic amine with some
pharmacologic activity similar to
that of the prototype drugs of this class used in obesity, the
amphetamines. Actions include some central
nervous system stimulation and elevation of blood pressure. Tolerance
has been demonstrated with all
drugs of this class in which these phenomena have been looked for.
Drugs of this class used in obesity are commonly known as
“anorectics” or “anorexigenics”. It has not
been established, however, that the action of such drugs in treating
obesity is primarily one of appetite
suppression. Other central nervous system actions or metabolic effects
may be involved, for example.
Adult obese subjects instructed in dietary management and treated with
“anorectic” drugs lose more
weight on the average than those treated with placebo and diet, as
determined in relatively short-term
clinical trials.
The magnitude of increased weight loss of drug-treated patients over
placebo-treated patients averages
some fraction of a pound a week. However, individual weight loss may
vary substantially from patient to
patient. The rate of weight loss