Երկիր: Ամերիկայի Միացյալ Նահանգներ
Լեզու: անգլերեն
Աղբյուրը: NLM (National Library of Medicine)
SULFAMETHOXAZOLE (UNII: JE42381TNV) (SULFAMETHOXAZOLE - UNII:JE42381TNV), TRIMETHOPRIM (UNII: AN164J8Y0X) (TRIMETHOPRIM - UNII:AN164J8Y0X)
Physicians Total Care, Inc.
SULFAMETHOXAZOLE
SULFAMETHOXAZOLE 400 mg
ORAL
PRESCRIPTION DRUG
Abbreviated New Drug Application
SULFAMETHOXAZOLE AND TRIMETHOPRIM - SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLET PHYSICIANS TOTAL CARE, INC. ---------- SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS, USP RX ONLY To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim; in tablets, each containing 400 mg sulfamethoxazole and 80 mg trimethoprim for oral administration. Sulfamethoxazole is _N_ -(5-methyl-3-isoxazolyl)sulfanilamide; the molecular formula is C H N O S. It is a white to off-white, practically odorless, crystalline powder, tasteless compound with a molecular weight of 253.28 and the following structural formula: Trimethoprim is 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; the molecular formula is C H N O . It is a white or cream-colored crystals or crystalline powder with a molecular weight of 290.3. and the following structural formula: INACTIVE INGREDIENTS: Docusate sodium, magnesium stearate, pregelatinized starch, sodium benzoate, and sodium starch glycolate. 1 10 11 3 3 14 18 4 3 CLINICAL PHARMACOLOGY Sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. The metabolism of sulfamethoxazole occurs predominately by N -acetylation, although the glucuronide conjugate has been identified. The principal metabolites of trimethoprim are the 1- and 3-oxides and the 3’- and 4’-hydroxy derivatives. The free forms of sulfamethoxazole and trimethoprim are considered to be the therapeutically active form Կարդացեք ամբողջական փաստաթուղթը