RIFAMPIN capsule coated

Երկիր: Ամերիկայի Միացյալ Նահանգներ

Լեզու: անգլերեն

Աղբյուրը: NLM (National Library of Medicine)

Ակտիվ բաղադրիչ:

Rifampin (UNII: VJT6J7R4TR) (Rifampin - UNII:VJT6J7R4TR)

Հասանելի է:

Cardinal Health

INN (Միջազգային անվանումը):

Rifampin

Կազմը:

Rifampin 300 mg

Ռեկվիզորի տեսակը:

PRESCRIPTION DRUG

Լիազորման կարգավիճակը:

Abbreviated New Drug Application

Ապրանքի հատկությունները

RIFAMPIN- RIFAMPIN CAPSULE, COATED
CARDINAL HEALTH
----------
RIFAMPIN CAPSULES, USP
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of rifampin
capsules USP and other antibacterial drugs, rifampin should be used
only to treat or prevent infections
that are proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Rifampin capsules, USP contain 150 mg or 300 mg rifampin per capsule.
The 150 mg and 300 mg
capsules also contain, as inactive ingredients: colloidal silicon
dioxide, corn starch, FD&C Blue No. 1,
FD&C Red No. 40, gelatin, lactose monohydrate, magnesium stearate,
sodium lauryl sulfate, talc, and
titanium dioxide.
The printing ink contains ammonium hydroxide, isopropyl alcohol,
n-butyl alcohol, pharmaceutical
glaze, propylene glycol, simethicone, and titanium dioxide
Rifampin is a semisynthetic antibiotic derivative of rifamycin SV.
Rifampin is a red-brown crystalline
powder very slightly soluble in water at neutral pH, freely soluble in
chloroform, soluble in ethyl
acetate and in methanol. Its molecular weight is 822.95 and its
chemical formula is C
H N O . The
chemical name for rifampin is either
3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin or
5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,20,22-heptamethyl-8-[N-(4-methyl-1-piper-
azinyl)formimidoyl]-2,7-(epoxypentadeca-[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione
21-
acetate. Its structural formula is:
CLINICAL PHARMACOLOGY
ORAL ADMINISTRATION
Rifampin is readily absorbed from the gastrointestinal tract. Peak
serum concentrations in healthy adults
and pediatric populations vary widely from individual to individual.
Following a single 600 mg oral
dose of rifampin in healthy adults, the peak serum concentration
averages 7 mcg/mL but may vary from 4
to 32 mcg/mL. Absorption of rifampin is reduced by about 30% when the
drug is ingested with food.
Rifampin is widely distributed throughout the body. It is present in
effective concentrations in many
organs and body fluids, including cerebr