PAPAVERINE HYDROCHLORIDE injection, solution

Երկիր: Ամերիկայի Միացյալ Նահանգներ

Լեզու: անգլերեն

Աղբյուրը: NLM (National Library of Medicine)

Ակտիվ բաղադրիչ:

PAPAVERINE HYDROCHLORIDE (UNII: 23473EC6BQ) (PAPAVERINE - UNII:DAA13NKG2Q)

Հասանելի է:

BPI Labs LLC

Կառավարման երթուղին:

PARENTERAL

Ռեկվիզորի տեսակը:

PRESCRIPTION DRUG

Թերապեւտիկ ցուցումներ:

Papaverine is recommended in various conditions accompanied by spasm of smooth muscle, such as vascular spasm associated with acute myocardial infarction (coronary occlusion), angina pectoris, peripheral and pulmonary embolism, peripheral vascular disease in which there is a vasospastic element, or certain cerebral angiospastic states, and visceral spasm , as in ureteral, biliary, or gastrointestinal colic. Intravenous injection of papaverine is contraindicated in the presence of complete atrioventricular heart block. When conduction is depressed, the drug may produce transient ectopic rhythms of ventricular origin, either premature beats or paroxysmal tachycardia. Papaverine Hydrochloride is not indicated for the treatment of impotence by intracorporeal injection. The intracorporeal injection of papaverine hydrochloride has been reported to have resulted in persistent priapism requiring medical and surgical intervention. Drug dependence resulting from the abuse of many of the selective depressants, includi

Ապրանքի ամփոփագիր:

Papaverine Hydrochloride Injection, USP, 30 mg/mL is available as  54288-142-10                                2mL Vial                                                  packaged in boxes of 10. 54288-142-25                                2mL Vial                                                  packaged in boxes of 25. Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) (See USP Controlled Room Temperature). PROTECT FROM LIGHT. RETAIN IN CARTON UNTIL TIME OF USE. Manufactured by: BPI Labs, LLC 12393 Belcher Rd S, Suite 450 Largo, FL USA 33773 LI33I R-2303

Լիազորման կարգավիճակը:

unapproved drug other

Ապրանքի հատկությունները

PAPAVERINE HYDROCHLORIDE- PAPAVERINE HYDROCHLORIDE INJECTION, SOLUTION
BPI LABS LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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PAPAVERINE HYDROCHLORIDE INJECTION, USP
RX ONLY
THIS PRODUCT IS TO BE USED BY OR UNDER THE DIRECTION OF A PHYSICIAN.
EACH VIAL CONTAINS A SUFFICIENT AMOUNT TO PERMIT WITHDRAWAL AND
ADMINISTRATION OF THE VOLUME SPECIFIED ON THE LABEL.
DESCRIPTION
Papaverine Hydrochloride, USP, is the hydrochloride of an alkaloid
obtained from opium
or prepared synthetically. It belongs to the benzylisoquinoline group
of alkaloids. It does
not contain a phenanthrene group as do morphine and codeine.
Papaverine Hydrochloride, USP, is 6,7-dimethoxy-1-
veratrylisoquinoline hydrochloride
and contains, on the dried basis, not less than 98.5% of C
H
NO
•HCl. The
molecular weight is 375.85. The structural formula is as shown.
Papaverine Hydrochloride occurs as white crystals or white crystalline
powder. One
gram dissolves in about 30 mL of water and in 120 mL of alcohol. It is
soluble in
chloroform and practically insoluble in ether.
Papaverine Hydrochloride Injection, USP, is a clear, colorless to
pale-yellow solution.
Papaverine Hydrochloride, for parenteral administration, is a
smooth-muscle relaxant
that is available in vials containing 30 mg/mL. Each vial also
contains edetate disodium
0.005%. pH may be adjusted with sodium citrate and/or citric acid.
CLINICAL PHARMACOLOGY
The most characteristic effect of papaverine is relaxation of the
tonus of all smooth
20
21
4
muscle, especially when it has been spasmodically contracted.
Papaverine Hydrochloride
apparently acts directly on the muscle itself. This relaxation is
noted in the _vascular_
_system_ and _bronchial musculature_ and in the _gastrointestinal,
biliary_ and _urinary tracts_.
The main actions of papaverine are exerted on cardiac and smooth
muscle. Papaverine
relaxes various smooth muscles, espec