MORPHINE SULFATE EXTENDED RELEASE- morphine sulfate tablet

Երկիր: Ամերիկայի Միացյալ Նահանգներ

Լեզու: անգլերեն

Աղբյուրը: NLM (National Library of Medicine)

Ակտիվ բաղադրիչ:

MORPHINE SULFATE (UNII: X3P646A2J0) (MORPHINE - UNII:76I7G6D29C)

Հասանելի է:

Lake Erie Medical DBA Quality Care Products LLC

INN (Միջազգային անվանումը):

MORPHINE SULFATE

Կազմը:

MORPHINE SULFATE 60 mg

Կառավարման երթուղին:

ORAL

Ռեկվիզորի տեսակը:

PRESCRIPTION DRUG

Թերապեւտիկ ցուցումներ:

Morphine sulfate extended-release tablets are an extended-release oral formulation of morphine sulfate indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. Morphine sulfate extended-release tablets are NOT intended for use as a prn analgesic. The morphine sulfate extended-release tablets 100 mg and 200 mg strengths are high dose, extended-release, oral morphine formulations indicated for the relief of pain in opioid-tolerant patients only. Morphine sulfate extended-release tablets are not indicated for pain in the immediate postoperative period (the first 12 to 24 hours following surgery) for patients not previously taking the drug, because its safety in this setting has not been established. Morphine sulfate extended-release tablets are not indicated for pain in the postoperative period if the pain is mild, or not expected to persist for an extended period of time. Morphine sulfate extended-release ta

Լիազորման կարգավիճակը:

Abbreviated New Drug Application

Ապրանքի հատկությունները

MORPHINE SULFATE EXTENDED RELEASE- MORPHINE SULFATE TABLET
LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC
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MORPHINE SULFATE ER 60 MG
DESCRIPTION
Morphine Sulfate Extended-Release Tablets are supplied in tablet form
for oral administration
CLINICAL PHARMACOLOGY
Morphine is a pure opioid agonist whose principal therapeutic action
is analgesia. Other members of
the class known as opioid agonists include substances such as
oxycodone, hydromorphone, fentanyl,
codeine, and hydrocodone. Pharmacological effects of opioid agonists
include anxiolysis, euphoria,
feelings of relaxation, respiratory depression, constipation, miosis,
cough suppression, and analgesia.
Like all pure opioid agonist analgesics, with increasing doses there
is increasing analgesia, unlike with
mixed agonist/antagonists or non-opioid analgesics, where there is a
limit to the analgesic effect with
increasing doses. With pure opioid agonist analgesics, there is no
defined maximum dose; the ceiling to
analgesic effectiveness is imposed only by side effects, the more
serious which may include
somnolence and respiratory depression.
Central Nervous System
The principal actions of therapeutic value of morphine are analgesia
and sedation (i.e., sleepiness and
anxiolysis).
The precise mechanism of the analgesic action is unknown. However,
specific CNS opiate receptors
for endogenous compounds with opioid-like activity have been
identified throughout the brain and
spinal cord and are likely to play a role in the expression of
analgesic effects.
Morphine produces respiratory depression by direct action on brain
stem respiratory centers. The
mechanism of respiratory depression involves a reduction in the
responsiveness of the brain stem
respiratory centers to increases in carbon dioxide tension, and to
electrical stimulation.
Morphine depresses the cough reflex by direct effect on the cough
center in the medulla. Antitussive
effects may occur with doses lower than those usually required for
analgesia. Morphine causes miosis,
even in total darkness. Pi