Country: Ամերիկայի Միացյալ Նահանգներ
language: անգլերեն
source: NLM (National Library of Medicine)
levothyroxine sodium (UNII: 9J765S329G) (levothyroxine - UNII:Q51BO43MG4)
Schering Corporation
levothyroxine sodium
levothyroxine sodium 1 mg in 1 mL
PRESCRIPTION
unapproved drug other
LEVENTA- LEVOTHYROXINE SODIUM SOLUTION SCHERING CORPORATION _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- LEVENTA 30ML Each mL of LEVENTA (levothyroxine sodium, U.S.P.) oral solution provides 1 mg synthetic crystalline levothyroxine sodium (L-thyroxine). CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATION Thyroid replacement therapy in dogs with hypothyroidism. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones, L-thyroxine (T ) and triiodothyronine (T ). LEVENTA oral solution will provide L-thyroxine (T ) as a substrate for the physiologic deiodination to triiodothyronine (T ). Administration of L-thyroxine (T ), identical to the L-thyroxine (T ) secreted endogenously by the normal thyroid gland, will result in complete physiologic thyroid replacement. L-thyroxine (T ) acts to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and the maturation rate of the epiphyses. The clinical diagnosis of hypothyroidism should be completed by evaluation of the thyroid hormone of the dog, i.e. measurement of serum levels of total (or preferably free) thyroxine (T ) and thyroid stimulating hormone (TSH). A low total (or free) T concentration combined with high TSH concentration is strongly suggestive for primary hypothyroidism. PHARMACOLOGY Levothyroxine sodium acts, as does endogenous L-thyroxine (T ), to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. DOSAGE The adequate dose rate has to be defined individually for each read_full_document