Երկիր: Կանադա
Լեզու: անգլերեն
Աղբյուրը: Health Canada
GLYCOPYRROLATE
JAMP PHARMA CORPORATION
A03AB02
GLYCOPYRRONIUM
0.2MG
SOLUTION
GLYCOPYRROLATE 0.2MG
INTRAMUSCULAR
15G/50G
Ethical
Active ingredient group (AIG) number: 0102396002; AHFS:
APPROVED
2022-10-31
PRODUCT MONOGRAPH GLYCOPYRROLATE INJECTION USP SOLUTION: 0.2 MG / ML FOR INTRAMUSCULAR (IM) OR INTRAVENOUS (IV) ADMINISTRATION ANTICHOLINERGIC JAMP Pharma Corporation 1310 rue Nobel Boucherville, Québec J4B 5H3 Date of Revision: October 27, 2022 Control # 262480 Page | 1 Page | 2 PRODUCT MONOGRAPH GLYCOPYRROLATE INJECTION USP 0.2 MG/ML THERAPEUTIC CLASSIFICATION ANTICHOLINERGIC CLINICAL PHARMACOLOGY Glycopyrrolate, like other anticholinergic (antimuscarinic) agents, competitively antagonizes the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. Glycopyrrolate antagonizes muscarinic symptoms (e.g., bronchorrhea, bronchospasm, bradycardia and intestinal hypermotility) induced by cholinergic drugs such as anticholinesterases. As a premedicant, Glycopyrrolate Injection USP reduces excessive pharyngeal, tracheal and bronchial secretions and, during anesthesia, it appears to protect the heart against excessive vagal stimulation. The polar ammonium moiety of glycopyrrolate limits its passage across lipid membranes such as the blood- brain barrier, in contrast to the belladonna alkaloids (such as atropine), which are nonpolar tertiary amines. Consequently, Glycopyrrolate Injection USP does not cause the central nervous system effects seen with the belladonna alkaloids. The onset of action following intramuscular injection of Glycopyrrolate Injection USP is 20 to 40 minutes. Peak effects occur approximately 30 to 45 minutes after administration and the duration of action ranges from 4 to 6 hours. With intravenous injection, the onset of action is generally evident within one minute; the duration of action varies, as does that of all other anticholinergics. Following intravenous glycopyrrolate, the vagal blocking effects persist for 2 to 3 hours and the antisialagogue effects persist up to 7 hours. INDICATIONS GASTROINTESTINAL DISORDERS: Glycopyrrolate Injection USP may be used in the management of gas Կարդացեք ամբողջական փաստաթուղթը