Country: Մալայզիա
language: անգլերեն
source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
GLIBENCLAMIDE; METFORMIN HYDROCHLORIDE
Noripharma Sdn. Bhd.
GLIBENCLAMIDE; METFORMIN HYDROCHLORIDE
10tablet Tablets; 20tablet Tablets; 10tablet Tablets; 30tablet Tablets; 50tablet Tablets; 60tablet Tablets; 90tablet Tablets; 100tablet Tablets; 120tablet Tablets; 180tablet Tablets; 500tablet Tablets; 1000tablet Tablets
Noripharma Sdn. Bhd.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ GLUCOMIN-G 500MG/2.5MG TABLET GLUCOMIN-G 500MG/5MG TABLET METFORMIN HYDROCHLORIDE 500MG/GLIBENCLAMIDE 2.5MG METFORMIN HYDROCHLORIDE 500MG/GLIBENCLAMIDE 5MG Page | 1 WHAT IS IN THIS LEAFLET: 1. WHAT GLUCOMIN-G IS USED FOR 2. HOW DOES GLUCOMIN-G WORKS 3. BEFORE YOU USE GLUCOMIN-G 4. HOW TO TAKE GLUCOMIN-G 5. WHILE USING GLUCOMIN-G 6. SIDE EFFECTS 7. STORAGE AND DISPOSAL OF GLUCOMIN-G 8. PRODUCT DESCRIPTION 9. MANUFACTURER AND PRODUCT REGISTRATION HOLDER 10. DATE OF REVISION 1. WHAT IS GLUCOMIN-G USE FOR Metformin and Glibenclamide is a combination of two oral diabetes medicines that help control blood sugar levels. GLUCOMIN-G is indicated as second-line therapy when diet, exercise and initial treatment with a sulfonylurea (Glibenclamide) or metformin do not result in controlling the patients’ glucose level in the blood of patients with type 2 diabetes patients. This medication is not for treating the type 1 diabetes. 2. HOW GLUCOMIN-G WORKS Metformin may act via 3 mechanisms; By reducing hepatic glucose production (net release of glucose from the liver). By inhibiting synthesizing of glucose and breakdown of glycogen in muscle, By increasing insulin sensitivity, improving peripheral glucose uptake and utilization and by delaying intestinal glucose absorption. Glibenclamide causes acute lowering of blood glucose by stimulating the release of insulin by the pancreas. 3. BEFORE YOU TAKE GLUCOMIN-G _WHEN YOU MUST NOT USE IT_ If you are allergic (hypersensitive) to Glibenclamide, metformin hydrochloride or any of the other ingredients of Glucomin-G. If you have kidney or liver function problems. Stop temporarily, if you need to have any type of x-ray or CT scan using a dye that is injected into your veins or if you need surgery. If you suffer from type 1 diabetes mellitus (i.e. insulin-dependent) or if you have severe loss of diabetes control with either pre-coma or ketosis (a condition caused by substances called ‘ketone bodies’ accumu read_full_document
1 GLUCOMIN-G 500MG/2.5MG TABLET GLUCOMIN-G 500MG/5MG TABLET COMPOSITION: GLUCOMIN-G 500MG/2.5MG Each film coated tablet contains 500mg of Metformin Hydrochloride and 2.5mg Glibenclamide. GLUCOMIN-G 500MG/5MG Each film coated tablet contains 500mg of Metformin Hydrochloride and 5mg Glibenclamide PRODUCT DESCRIPTION: GLUCOMIN-G 500MG/2.5MG: A beige coloured oblong shaped film coated tablet GLUCOMIN-G 500MG/5MG: A yellow coloured oblong shaped film coated tablet PHARMACODYNAMIC: Metformin is a biguanide with antihyperglycemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycemia. Metformin may act via 3 mechanisms: By reducing hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis; in muscle, By increasing insulin sensitivity, improving peripheral glucose uptake and utilization By delaying intestinal glucose absorption. Metformin stimulates intracellular glycogen synthesis by acting on glycogen synthase. Metformin increases the transport capacity of all types of membrane glucose transporters (GLUT). Glibenclamide is a second generation sulfonylurea with a short half-life. It causes acute lowering of blood glucose by stimulating the release of insulin by the pancreas, this effect being dependent on the presence of functioning β-cells in the islets of Langerhans. The mechanism by which Glibenclamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in patients with type 2 diabetes, the blood glucose-lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extra pancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. PHARMACOKINETICS: _Absorbtion: _ Metformin HCl: Metformin absorbtion is saturable and incomplete after the oral administration. It is assumed that the pharmacokinetics of metformin absorption is non-linear. At usual metformin doses read_full_document