FOLIC ACID tablet

Երկիր: Ամերիկայի Միացյալ Նահանգներ

Լեզու: անգլերեն

Աղբյուրը: NLM (National Library of Medicine)

Ակտիվ բաղադրիչ:

folic acid (UNII: 935E97BOY8) (folic acid - UNII:935E97BOY8)

Հասանելի է:

McKesson Contract Packaging

INN (Միջազգային անվանումը):

folic acid

Կազմը:

folic acid 1 mg

Ռեկվիզորի տեսակը:

PRESCRIPTION DRUG

Լիազորման կարգավիճակը:

Abbreviated New Drug Application

Ապրանքի հատկությունները

FOLIC ACID- FOLIC ACID TABLET
MCKESSON CONTRACT PACKAGING
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FOLIC ACID TABLETS, USP
RX ONLY
DESCRIPTION
Folic acid, N-[ρ-[[(2-amino-4-hydroxy-6-pteridinyl)
methyl]-amino]benzoyl]-L-glutamic acid, is a B
complex vitamin containing a pteridine moiety linked by a methylene
bridge to para-aminobenzoic acid,
which is joined by a peptide linkage to glutamic acid. Conjugates of
folic acid are present in a wide
variety of foods, particularly liver, kidneys, yeast, and leafy green
vegetables. Commercially available
folic acid is prepared synthetically. Folic acid occurs as a yellow or
yellowish-orange crystalline
powder and is very slightly soluble in water and insoluble in alcohol.
Folic acid is readily soluble in
dilute solutions of alkali hydroxides and carbonates and solutions of
the drug may be prepared with the
aid of sodium hydroxide or sodium carbonate, thereby forming the
soluble sodium salt of folic acid
(sodium folate). Aqueous solutions of folic acid are heat sensitive
and rapidly decompose in the
presence of light and/or riboflavin; solutions should be stored in a
cool place protected from light.
The structural formula of folic acid is as follows:
The molecular formula is C
H N O and the molecular weight is 441.40.
Each tablet, for oral administration, contains 1 mg folic acid.
Folic Acid Tablets, USP 1 mg contains the following inactive
ingredients: colloidal silicon dioxide,
lactose monohydrate, microcrystalline cellulose, sodium starch
glycolate and stearic acid.
CLINICAL PHARMACOLOGY
Folic acid acts on megaloblastic bone marrow to produce a
normo-blastic marrow.
In man, an exogenous source folate is required for nucleo-protein
synthesis and the maintenance of
normal erythropoiesis. Folic acid is the precursor of tetrahydrofolic
acid, which is involved as a
cofactor for transformylation reactions in the biosynthesis of purines
and thymidylates of nucleic acids.
Impairment of thymidylate synthesis in patients with folic acid
deficiency is thought to account for the
defective deoxyribonucleic acid