COXIB-200 CAPSULES 200MG

Երկիր: Սինգապուր

Լեզու: անգլերեն

Աղբյուրը: HSA (Health Sciences Authority)

Ակտիվ բաղադրիչ:

Celecoxib

Հասանելի է:

NAINA MOHAMED & SONS PRIVATE LIMITED

ATC կոդը:

M01AH01

Դեղագործական ձեւ:

CAPSULE

Կազմը:

Celecoxib 200mg

Կառավարման երթուղին:

ORAL

Ռեկվիզորի տեսակը:

Prescription Only

Պատրաստված է:

Micro Labs Limited

Լիազորման կարգավիճակը:

ACTIVE

Հաստատման ամսաթիվը:

2020-10-22

Ապրանքի հատկությունները

1
COXIB-200
CELECOXIB CAPSULES 200 MG
PRODUCT NAME
COXIB, Celecoxib capsules 200 mg
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S):
Celecoxib 200 mg
PRODUCT DESCRIPTION:
White opaque/White opaque, size ‘1’ hard gelatin capsule printed
with ‘M’ on cap and 13 on the body, filled with white to off white
granular
powder
LIST OF EXCIPIENTS:
Lactose Monohydrate, Croscarmellose Sodium, Povidone K-30, Sodium
lauryl Sulfate, Croscarmellose Sodium, Magnesium stearate, Gelatin,
Titanium Dioxide, Black Iron Oxide, Butyl Alcohol, Dehydrated Alcohol,
Isopropyl Alcohol, Potassium Hydroxide, Shellac, Strong Ammonia
Solution
PHARMACODYNAMICS/PHARMACOKINETICS:
_PHARMACODYNAMICS:_
Pharmacotherapeutic Group: Coxibs. ATC Code: M01AH.
Pharmacology: Pharmacodynamics: Mechanism of Action: The mechanism of
action of celecoxib is via inhibition of prostaglandin synthesis
primarily by inhibition of cyclooxygenase 2 (COX-2). At therapeutic
concentrations in humans celecoxib does not inhibit cyclooxygenase 1
(COX-1). COX-2 is induced in response to inflammatory stimuli. This
leads to the synthesis and accumulation of inflammatory prostanoid, in
particular prostaglandin E2, causing inflammation, edema and pain.
Celecoxib acts as an anti-inflammatory, analgesic, and antipyretic
agent in
animal models by blocking the production of inflammatory prostanoid
via COX-2 inhibition. In animal colon tumor models, celecoxib reduced
the incidence and multiplicity of tumors.
In vivo and ex vivo studies show that celecoxib has a very low
affinity for the constitutively expressed COX-1 enzyme. Consequently
at
therapeutic doses celecoxib has no effect on prostanoid synthesized by
activation of COX-1 thereby not interfering with normal COX-1 related
physiological processes in tissues, particularly the stomach,
intestine, and platelets.
_CLINICAL STUDIES_
_Osteoarthritis (OA): _ Celecoxib has demonstrated significant
reduction in joint pain compared to placebo. Celecoxib was evaluated
for
treatment of the signs and the symptoms of OA of the knee and hip in
a