Երկիր: Կանադա
Լեզու: անգլերեն
Աղբյուրը: Health Canada
AMPICILLIN
APOTEX INC
J01CA01
AMPICILLIN
125MG
LIQUID
AMPICILLIN 125MG
ORAL
60/100/150ML
Prescription
AMINOPENICILLINS
Active ingredient group (AIG) number: 0105872006; AHFS:
CANCELLED POST MARKET
2019-04-05
Page 1 of 8 PRESCRIBING INFORMATION Including Patient Medication Information APO-AMPI Ampicillin Trihydrate, USP 250 and 500 mg Capsules 125 mg per 5 mL 250 mg per 5 mL Powder for Oral Suspension ANTIBIOTIC APOTEX INC. 150 SIGNET DRIVE TORONTO, ONTARIO M9L1T9 CONTROL NO: 217173 DATE OF PREPARATION: March 20, 2019 Page 2 of 8 PHARMACOLOGY: Ampicillin, a semisynthetic penicillin, is similar to benzylpenicillin in its bactericidal action against sensitive organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide. Ampicillin differs in vitro spectrum from benzylpenicillin in the gram-negative spectrum. It exerts high in vitro activity against many strains of H. influenzae, N. gonorrhoeae, N. meningitidis, B. catarrhalis, E. coli, P. mirabilis, B. funduliformis, Salmonellae and Shigellae. In vitro studies have also demonstrated the sensitivity of many strains of the following gram positive bacteria: alpha-and beta-hemolytic streptococci, S. pneumoniae, non-beta-lactamase (penicillinase)- producing staphylococci, B. anthracis, and most strains of enterococci and clostridia. Ampicillin generally provides less in vitro activity than penicillin G against gram positive bacteria. Because it does not resist destruction by beta-lactamase, it is not effective against beta-lactamase-producing bacteria, particularly resistant staphylococci. All strains of Pseudomonas and most strains of Klebsiella and Aerobacter are resistant. Ampicillin is not active against Rickettsia, Mycoplasma and 'large viruses' (Chiamydia). Ampicillin is acid stable and therefore, well absorbed. Food, however, retards absorption. Ampicillin diffuses readily into most body tissues and fluids; however, penetration into the cerebrospinal fluid and brain occurs only with meningeal inflammation. Ampicillin is excreted largely unchanged in the urine; its excretion can be delayed by concurrent administration of probenecid. In blood serum, ampicillin is the least bound of all the penicillins; an a Կարդացեք ամբողջական փաստաթուղթը