ACYCLOVIR tablet

Երկիր: Ամերիկայի Միացյալ Նահանգներ

Լեզու: անգլերեն

Աղբյուրը: NLM (National Library of Medicine)

Ակտիվ բաղադրիչ:

ACYCLOVIR (UNII: X4HES1O11F) (ACYCLOVIR - UNII:X4HES1O11F)

Հասանելի է:

AvPAK

INN (Միջազգային անվանումը):

ACYCLOVIR

Կազմը:

ACYCLOVIR 400 mg

Կառավարման երթուղին:

ORAL

Ռեկվիզորի տեսակը:

PRESCRIPTION DRUG

Թերապեւտիկ ցուցումներ:

Acyclovir is indicated for the acute treatment of herpes zoster (shingles). Acyclovir is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Acyclovir is indicated for the treatment of chickenpox (varicella). Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

Ապրանքի ամփոփագիր:

Acyclovir Tablets, 800 mg (white to off-white, unscored, oval and engraved with “CTI; 113 ”) NDC 50268-062-15 10 Tablets per card, 5 cards per carton. Acyclovir Tablets, 400 mg (white to off-white, unscored, oval and engraved with “CTI; 112 ”) NDC 50268-061-15 10 tablets per card, 5 cards per carton Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Protect from moisture. Keep this and all medication out of the reach of children. Dispensed in Blister Punch Material. For Institutional Use Only. Manufactured for: AvKARE Pulaski, TN 38478 Mfg. Rev. 04/13 AV Rev. 06/23 (M)

Լիազորման կարգավիճակը:

Abbreviated New Drug Application

Ապրանքի հատկությունները

ACYCLOVIR- ACYCLOVIR TABLET
AVPAK
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ACYCLOVIR TABLETS USP
DESCRIPTION
Acyclovir is a synthetic nucleoside analogue active against
herpesviruses. Acyclovir
tablets are formulations of an antiviral drug for oral administration.
Each 800-mg tablet of acyclovir contains 800 mg of acyclovir and the
inactive
ingredients corn starch, microcrystalline cellulose, magnesium
stearate, and sodium
starch glycolate.
Each 400-mg tablet of acyclovir contains 400 mg of acyclovir and the
inactive
ingredients corn starch, microcrystalline cellulose, magnesium
stearate, and sodium
starch glycolate.
Acyclovir is a white, crystalline powder with the molecular formula
C8H11N5O3 and a
molecular weight of 225. The maximum solubility in water at 37°C is
2.5 mg/mL. The
pka’s of acyclovir are 2.27 and 9.25.
The chemical name of acyclovir is 6 _H_-purin-6-one, 2-amino-1,9-
dihydro-9-[(2-
hydroxyethoxy)methyl]; it has the following structural formula:
VIROLOGY
MECHANISM OF ANTIVIRAL ACTION
Acyclovir is a synthetic purine nucleoside analogue with _in vitro_
and _in vivo_ inhibitory
activity against herpes simplex virus types 1 (HSV-1), 2 (HSV- 2), and
varicella-zoster
virus (VZV). The inhibitory activity of acyclovir is highly selective
due to its affinity for the
enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme
converts
acyclovir into acyclovir monophosphate, a nucleotide analogue. The
monophosphate is
further converted into diphosphate by cellular guanylate kinase and
into triphosphate by
a number of cellular enzymes. _In vitro_, acyclovir triphosphate stops
replication of herpes
viral DNA. This is accomplished in 3 ways: 1) competitive inhibition
of viral DNA
polymerase, 2) incorporation into and termination of the growing viral
DNA chain, and 3)
inactivation of the viral DNA polymerase. The greater antiviral
activity of acyclovir against
HSV compared to VZV is due to its more efficient phosphorylation by
the viral TK.
ANTIVIRAL ACTIVITIES
The quantitative relationship between the _in vitro_ susceptibility