GLUCOMIN 850MG TABLET

Ország: Malajzia

Nyelv: angol

Forrás: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktív összetevők:

METFORMIN HYDROCHLORIDE

Beszerezhető a:

Noripharma Sdn. Bhd.

INN (nemzetközi neve):

METFORMIN HYDROCHLORIDE

db csomag:

1000tablet Tablets; 10tablet Tablets; 30tablet Tablets; 100tablet Tablets; 500tablet Tablets

Gyártó:

Noripharma Sdn. Bhd.

Betegtájékoztató

_Consumer Medication Information Leaflet (RiMUP) _
GLUCOMIN 850MG TABLET
Metformin Hydrochloride 850mg
Page | 1
WHAT IS IN THIS LEAFLET
1.
What Glucomin 850 is used for?
2.
How Glucomin 850 works
3.
Before you use Glucomin 850
4.
How to take Glucomin 850
5.
While you are using Glucomin 850
6.
Side effects
7.
Storage and disposal of Glucomin
850
8.
Product description
9.
Manufacturer
and
product
registration Holder
10.
Date of revision
WHAT GLUCOMIN 850 IS USED FOR?
Metformin is used for the sort of
diabetes called Type 2 diabetes or non-
insulin-dependent diabetes mellitus.
HOW GLUCOMIN 850 WORKS
•
In type 2 diabetes, there is too much
sugar (glucose) in your blood. This
is because your body does not make
enough insulin or because it makes
insulin that does not work properly.
•
Insulin is a hormone that allows
your body tissue to take glucose
from the blood and use it for energy
or for storage for future use.
•
Metformin works by improving the
sensitivity of your body to insulin.
It helps your body to use glucose in
the normal way again
BEFORE YOU USE GLUCOMIN 850
_When you must not take it _
•
you are allergic (hypersensitive) to
metformin
or
any
of
the
other
ingredients
•
you have recently had a heart attack
or any other heart problems
•
you
have
severe
circulation
problems or difficulty in breathing
•
you have liver or kidney problems
•
you have had serious problems with
your
diabetes
in
the
past
called
diabetic
ketoacidosis.
When
you
have this you lose weight quickly,
feel
sick
(nausea)
or
are
sick
(vomiting).
•
you
have
recently
had
a
severe
infection, injury or trauma (shock)
•
you are dehydrated
•
you are going to have an X-ray
where you will be injected with a
dye
•
you are a heavy drinker of alcohol
(more than 21 units a week for a
man
or
14
units
a
week
for
a
woman). A unit is equivalent to a
small glass of wine, one shot or half
a pint of beer.
•
you are pregnant, planning to get
pregnant or are breast-feeding
•
If
you
have
severely
reduced
kidney function.
•
If
you
have
l

Termékjellemzők

GLUCOMIN 850MG TABLET
DESCRIPTION:
A white to off white oblong shaped film coated tablet.
COMPOSITION:
Each film coated tablet contains 850mg Metformin HCl equivalent to
Metformin.
PHARMACODYNAMIC:
Metformin is a biguanide derivative of guanidine, used for treating
type II diabetes mellitus. It has
antihyperglycaemic effects, which lowers both basal and postprandial
plasma glucose. It does not
increase insulin secretion and hence, does not cause hypoglycaemia.
Metformin acts via 3 mechanisms:

reduction in hepatic glucose production,

reduction in intestinal glucose absorption, and

Increased insulin sensitivity (improved peripheral glucose uptake and
utilization).
Metformin stimulates intracellular glycogen synthesis by acting on
glycogen synthase. Metformin
increases the transport capacity of all types of membrane glucose
transporters (GLUTs).In humans,
independently of its action on glycaemia, metformin has favourable
effects on lipid metabolism.
PHARMACOKINETICS:
_Absorption_
:
After an oral dose of metformin hydrochloride tablet, maximum plasma
concentration (Cmax) is
reached in approximately 2.5 hours (tmax).
Metformin hydrochloride is slowly and incompletely absorbed from the
gastrointestinal tract.
It is assumed that the pharmacokinetics of metformin absorption is
non-linear.
Bioavailability for oral metformin is approximately 50-60% in healthy
subjects.
Dose proportionally is lacking due to decreasing absorption with
increasing doses.
Steady state plasma concentrations for metformin are reached within 24
to 48 hours and are generally
less than 1 microgram/ml at recommended doses and dosing schedules.
Food decreases the extent and delays the time to achieve maximum
absorption. The plasma peak
concentration may be 40% lower with food administration.
_Distribution_
:
Plasma protein-binding is negligible.
Metformin crosses the placenta and is distributed into breast milk in
small amounts.
Metformin partitions into erythrocytes.
_ The blood peak is lower than the plasma peak and appears at _
_approxi