Formet Aspen 850

Ország: Ausztrália

Nyelv: angol

Forrás: Department of Health (Therapeutic Goods Administration)

Aktív összetevők:

Metformin hydrochloride

Beszerezhető a:

Aspen Pharma Pty Ltd

Osztály:

Medicine Registered

Termékjellemzők

FORMET ASPEN- Product Information 

Page 1 of 9 
PRODUCT INFORMATION 

FORMET ASPEN 500 AND 
FORMET ASPEN 850 

LIFE THREATENING LACTIC ACIDOSIS CAN OCCUR DUE TO
ACCUMULATION OF METFORMIN. RISK 
FACTORS INCLUDE RENAL IMPAIRMENT,
OLD AGE AND THE USE OF HIGH DOSES OF METFORMIN ABOVE 
2 G PER DAY. 

NAME OF THE MEDICINE  

Metformin hydrochloride. 
[http://www.appco.com.au/appguide/drug.asp?drug_id=00202405]

The chemical name for metformin hydrochloride is
1, 1-dimethylbiguanide hydrochloride. 

C
4
H
11
N
5
•HCl 
Molecular weight: 165.6  
Cas No: 1115-70-4  

DESCRIPTION

Metformin hydrochloride is a white, crystalline powder which is
odourless or almost 
odourless and hygroscopic. It is freely soluble in water,
slightly soluble in ethanol (96%), and 
practically insoluble in chloroform and ether.  

FORMET ASPEN tablets are available in two strengths and contain
either 500 mg or 850 mg 
of metformin hydrochloride. The tablets also contain
the following excipients: sodium starch 
glycollate type A, povidone, maize starch, magnesium stearate, colloidal
anhydrous silica, 
hypromellose, macrogol 6000, purified talc, titanium dioxide and
propylene glycol. The 
tablets are gluten free.  

NH
N
H
2
N
CH
3
CH
3
NH
NH
, HCl 
FORMET ASPEN- Product Information 

Page 2 of 9 
PHARMACOLOGY

Metformin is an oral biguanide hypoglycaemic agent. It causes an
increased peripheral 
uptake of glucose by increasing the biological
efficiency of available exogenous or 
endogenous insulin.  

The mode of action of metformin may be linked to an increase of
insulin sensitivity. It does 
not stimulate insulin release but does require the presence of
insulin to exert its 
hypoglycaemic effect. Possible mechanisms of action include
inhibition of gluconeogenesis 
in the liver, delay in glucose absorption from
the gastrointestinal tract and an in