DISULFIRAM tablet

Ország: Egyesült Államok

Nyelv: angol

Forrás: NLM (National Library of Medicine)

Aktív összetevők:

DISULFIRAM (UNII: TR3MLJ1UAI) (DISULFIRAM - UNII:TR3MLJ1UAI)

Beszerezhető a:

Bryant Ranch Prepack

INN (nemzetközi neve):

DISULFIRAM

Összetétel:

DISULFIRAM 500 mg

Recept típusa:

PRESCRIPTION DRUG

Engedélyezési státusz:

Abbreviated New Drug Application

Termékjellemzők

DISULFIRAM- DISULFIRAM TABLET
BRYANT RANCH PREPACK
----------
DISULFIRAM TABLETS, USP
IN ALCOHOLISM
WARNING:
Disulfiram should _never_ be administered to a patient when he is in a
state of alcohol intoxication,
or without his full knowledge.
The physician should instruct relatives accordingly.
DESCRIPTION:
Disulfiram is an alcohol antagonist drug.
CHEMICAL NAME:
bis(diethylthiocarbamoyl) disulfide.
STRUCTURAL FORMULA:
Disulfiram occurs as a white to off-white, odorless, and almost
tasteless powder, soluble in water to
the extent of about 20 mg in 100 mL, and in alcohol to the extent of
about 3.8 g in 100 mL.
Each tablet for oral administration contains 250 mg or 500 mg
disulfiram, USP. Tablets also contain
crospovidone, lactose monohydrate, magnesium stearate,
microcrystalline cellulose, povidone and
silicon dioxide.
CLINICAL PHARMACOLOGY:
Disulfiram produces a sensitivity to alcohol which results in a highly
unpleasant reaction when the
patient under treatment ingests even small amounts of alcohol.
Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage.
During alcohol metabolism
following disulfiram intake, the concentration of acetaldehyde
occurring in the blood may be 5 to 10
times higher than that found during metabolism of the same amount of
alcohol alone.
Accumulation of acetaldehyde in the blood produces a complex of highly
unpleasant symptoms referred
to hereinafter as the disulfiram-alcohol reaction. This reaction,
which is proportional to the dosage of
both disulfiram and alcohol, will persist as long as alcohol is being
metabolized. Disulfiram does not
appear to influence the rate of alcohol elimination from the body.
Disulfiram is absorbed slowly from the gastrointestinal tract and is
eliminated slowly from the body.
One (or even two) weeks after a patient has taken his last dose of
disulfiram, ingestion of alcohol may
produce unpleasant symptoms.
Prolonged administration of disulfiram does not produce tolerance; the
longer a patient remains on
therapy, the more exquisitely sensitive he