DBL NALOXONE HYDROCHLORIDE

Ország: Ausztrália

Nyelv: angol

Forrás: Department of Health (Therapeutic Goods Administration)

Aktív összetevők:

Naloxone hydrochloride

Beszerezhető a:

Hospira Australia Pty Ltd

Osztály:

Medicine Registered

Betegtájékoztató

DBL™

Naloxone Hydrochloride Injection 

Page  1 
DBL™ NALOXONE HYDROCHLORIDE 
INJECTION

Naloxone Hydrochloride    _(nal-OX-own)_
_ _

CONSUMER MEDICINE INFORMATION 
_Date of Dispensing_

_Consumer Name _
_Pharmacist Name _
_Consumer Address _
_Pharmacist Address _

WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about DBL™

Naloxone Hydrochloride 
Injection (naloxone). 

It does not contain all the 
available information. 

It does not take the place of 
talking to your doctor or 
pharmacist. 

All medicines have risks and 
benefits.  Your doctor or 
pharmacist has weighed the 
risks of you being given DBL™ 
Naloxone Hydrochloride 
Injection against the benefits 
they expect it will have for you. 

IF YOU HAVE ANY CONCERNS 
ABOUT BEING GIVEN THIS 
MEDICINE, ASK YOUR DOCTOR OR 
PHARMACIST. 

KEEP THIS LEAFLET IN A SAFE 
PLACE. 
You may need to read it again. 

WHAT DBL™

NALOXONE 
HYDROCHLORIDE 
INJECTION IS USED FOR 

Naloxone is a medicine which, 
when injected, reverses the 
effect of opium-like substances 
such as morphine, heroin and 
codeine.   

It acts very quickly, within one or 
two minutes when injected into a 
vein, and can be a lifesaving 
measure in those people who 
have received an overdose of an 
opioid-like drug.   

It may also used after surgical 
operations when powerful pain 
killers which have been given 
during the operation are no 
longer required. 

Your doctor may have 
prescribed naloxone for another 
reason.  Ask your doctor if you 
have any questions about why 
naloxone has been prescribed 
for you. 

DBL™

Naloxone Hydrochloride 
Injection is not addictive. 

This medicine is available only 
with a doctor’s prescription. 

BEFORE YOU ARE GIVEN 
DBL™

NALOXONE 
HYDROCHLORIDE 
INJECTION 

_WHEN YOU MUST NOT BE _
_GIVEN IT _
�

Termékjellemzők

Product Information – Australia 

Version 4.0 
Page  
1

DBL™ NALOXONE HYDROCHLORIDE INJECTION 

NAME OF THE MEDICINE 
Naloxone hydrochloride 

Its chemical structure is shown below:

HO
OH
N
O
O
.HCl
CH
2
H

The chemical formula for anhydrous naloxone hydrochloride is C
19
H
21
NO
4.
HCl.  Its molecular weight 
is 363.84 and its CAS registry number is 357-08-4. 

DESCRIPTION 
Naloxone is a semi-synthetic opioid antagonist which differs structurally from oxymorphone only
in 
that the methyl group on the nitrogen atom of oxymorphone is
replaced by an allyl group.   

Naloxone hydrochloride is 17-allyl-4,5 α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride.   

Naloxone hydrochloride occurs as a white to
slightly off-white powder and is soluble in water, dilute 
acids and strong alkalis and is slightly soluble in alcohol.  It is
practically insoluble in ether or 
chloroform. 

DBL™ Naloxone Hydrochloride Injection is a sterile, clear,
colourless solution, free from visible 
particulates.  It is available as 400 micrograms/1
mL containing sodium chloride in water for 
injections. The preparation has a pH of approximately 3.5. 

PHARMACOLOGY 
PHARMACODYNAMICS 
Naloxone is essentially a pure opioid antagonist,
it has little or no agonistic activity.  Naloxone is 
thought to act as a competitive antagonist at mu, kappa, and sigma
opioid receptors in the central 
nervous system (CNS), although the precise mechanism of action
has not been fully determined. 
Naloxone prevents or reverses the effects of opioids, including respiratory depression, sedation and 
hypotension.  Naloxone can also reverse the psychotomimetic and
dysphoric effects of agonist-
antagonists such as pentazocine, but higher doses are
required.  One milligram of naloxone 
intravenously completely blocks the effects of 25 milligrams of
diacet