Crixivan

Ország: Ausztrália

Nyelv: angol

Forrás: Department of Health (Therapeutic Goods Administration)

Aktív összetevők:

Indinavir sulfate

Beszerezhető a:

Merck Sharp & Dohme Australia Pty Ltd

Osztály:

Medicine Listed (Export Only)

Betegtájékoztató

CRIXIVAN
®

_Indinavir sulfate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about CRIXIVAN. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking CRIXIVAN
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR, PHARMACIST OR TREATMENTS
OFFICER AT YOUR LOCAL AIDS COUNCIL.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT CRIXIVAN IS
USED FOR
CRIXIVAN, a protease inhibitor, is
used to help treat HIV (Human
Immunodeficiency Virus) infection.
It should be used in combination with
other appropriate medicines used to
treat HIV. If combination therapy is
not possible it may be used alone.
CRIXIVAN can be used in adults,
and children 3 years of age and older
who can swallow capsules.
CRIXIVAN belongs to a group of
medicines called HIV protease
inhibitors. It works in a different way
to the other medicines used to treat
HIV. CRIXIVAN works by
interrupting the formation of new
HIV particles in already infected
cells. When HIV is attacked by
CRIXIVAN, the virus is not able to
reproduce normally. This helps
reduce the amount of virus in the
body and helps protect new cells
from infection. CRIXIVAN helps
reduce the amount of virus in the
body and thus increases the CD4
count.
You may continue to develop
infections or other illnesses
associated with HIV disease while
you are taking CRIXIVAN.
BEFORE YOU TAKE
CRIXIVAN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE CRIXIVAN IF:
•
YOU HAVE AN ALLERGY TO
CRIXIVAN OR ANY OF THE
INGREDIENTS LISTED AT THE END OF
THIS LEAFLET
•
THE PACKAGING IS TORN OR SHOWS
SIGNS OF TAMPERING
•
THE EXPIRY DATE ON THE PACK HAS
PASSED.
 If you take this medicine after the
expiry date has passed, it may not
work.
IF YOU ARE NOT SURE WHETHER YOU
SHOULD START TAKING CRIXIVAN,
TALK TO YOUR DOCTOR.
_B

Termékjellemzők

CRX-C-052013

1 
PRODUCT INFORMATION 

CRIXIVAN


(INDINAVIR SULFATE) 

CAPSULES 

NAME OF THE DRUG 

Indinavir sulfate 

DESCRIPTION 

CRIXIVAN (indinavir sulfate) is a specific protease
inhibitor active against the Human 
Immunodeficiency Virus (HIV-1).   

The chemical name
for indinavir sulfate is (2_R_,4_S_)-2-benzyl-5-[(2_S_)-2- [(tert-butylamino) 
carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-_N_-[(1S,2_R_)-2,3-dihydro-2-hydroxy-1-indenyl] -
4-hydroxypentamide sulfate (1:1) (salt).  Indinavir sulfate has the following structural 
formula:  

Indinavir sulfate is a white to
off-white, free-flowing crystalline powder with the molecular 
formula C36H47N5O4 

 H2SO4 and
a molecular weight of 711.88.  The CAS number is 
157810-81-6.   

CRIXIVAN capsules are formulated as
a sulfate salt and are available for oral 
administration in strengths of 100, 200 and
400mg of indinavir (corresponding to 125, 250 
and 500mg indinavir sulfate, respectively.) 

In addition to the active ingredient indinavir sulfate, each
capsule contains the following 
inactive
ingredients: anhydrous lactose, magnesium stearate, gelatin, titanium dioxide, 
silicon dioxide and sodium lauryl sulfate. 

PHARMACOLOGY 

Indinavir inhibits purified HIV-1 and HIV-2 protease with
an approximate tenfold selectivity 
for HIV-1 over HIV-2.  The compound binds directly to
the protease active site and, as such, 
is a competitive
inhibitor of the enzyme.  This inhibition prevents cleavage
of the viral 
precursor polyprotein that occurs during maturation
of the newly formed viral particle. The 
resulting immature particles are non-infectious and are incapable
of establishing new cycles 
of infection. Indinavir did
not significantly inhibit other eukaryotic proteases
including human 
renin, human cathepsin D, human elas