Ország: Egyesült Államok
Nyelv: angol
Forrás: NLM (National Library of Medicine)
Cimetidine Hydrochloride (UNII: WF10491673) (Cimetidine - UNII:80061L1WGD)
Morton Grove Pharmaceuticals, Inc.
Cimetidine Hydrochloride
Cimetidine 300 mg in 5 mL
PRESCRIPTION DRUG
Abbreviated New Drug Application
CIMETIDINE HYDROCHLORIDE- CIMETIDINE HYDROCHLORIDE SOLUTION MORTON GROVE PHARMACEUTICALS, INC. ---------- CIMETIDINE HYDROCHLORIDE ORAL SOLUTION 300 MG/5 ML DESCRIPTION Cimetidine is a histamine H receptor-antagonist. Chemically it is _N"_-cyano-_N_-methyl-_N'_-[2-[[(5- methyl-1_H_-imidazol-4-yl)methyl]thio]-ethyl]-guanidine. The molecular formula for cimetidine hydrochloride is C H N S • HCl and the molecular weight is 288.80. The structural formula is: Cimetidine contains an imidazole ring, and is chemically related to histamine. Cimetidine has a bitter taste and characteristic odor. SOLUBILITY CHARACTERISTICS Cimetidine hydrochloride is freely soluble in water, soluble in alcohol, very slightly soluble in chloroform and practically insoluble in ether. Each of 5 mL (1 teaspoonful) contains: Cimetidine hydrochloride equivalent to cimetidine 300 mg and alcohol 2.8%. The pH range is between 5.3 and 6.2. Inactive Ingredients: FD&C Yellow No. 6; Methylparaben, NF; Natural and Artificial Peach Flavor; Propylene Glycol, USP; Propylparaben, NF; Purified Water, USP; Saccharin Sodium, USP; Sodium Chloride, USP; Sodium Phosphate Dibasic, USP and Sorbitol Solution, USP. IT MAY ALSO CONTAIN Sodium Phosphate Monobasic, USP to adjust pH. CLINICAL PHARMACOLOGY Cimetidine competitively inhibits the action of histamine at the histamine H receptors of the parietal cells and thus is a histamine H -receptor antagonist. Cimetidine is not an anticholinergic agent. Studies have shown that cimetidine inhibits both daytime and nocturnal basal gastric acid secretion. Cimetidine also inhibits gastric acid secretion stimulated by food, histamine, pentagastrin, caffeine and insulin. ANTISECRETORY ACTIVITY 1) Acid Secretion _Nocturnal_ Cimetidine 800 mg orally at bedtime reduces mean hourly H activity by greater than 85% over an 8- 2 10 16 6 2 2 + hour period in duodenal ulcer patients, with no effect on daytime acid secretion. Cimetidine 1600 mg orally h.s. produces 100% inhibition of mean hourly H activity over an 8-hour period in duoden Olvassa el a teljes dokumentumot