Država: Australija
Jezik: engleski
Izvor: Department of Health (Therapeutic Goods Administration)
Clindamycin phosphate
Actavis Pty Ltd
Medicine Registered
ZINDACLIN ® 1%W/W CLINDAMYCIN (_AS CLINDAMYCIN PHOPSHATE_) CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET? Important information you should read before you use Zindaclin. Please read this leaflet carefully before you use Zindaclin. It contains a summary of the information about your medicine. If you have any questions about Zindaclin, please ask your doctor or pharmacist. Keep the leaflet with the medicine – you may need to read it again. REMEMBER This medicine is only for you. Only a doctor can prescribe it for you. Never give it to other people. It may harm them, even though their symptoms may seem to be the same as yours. WHAT IS ZINDACLIN USED FOR? Zindaclin is used to treat acne (spots). Zindaclin contains clindamycin phosphate which breaks down in the skin to clindamycin which is an antibiotic. Zindaclin reduces the number of bacteria. This will help to stop the pores becoming blocked and new spots forming. Zindaclin may also help to reduce the redness of the spots you already have. As with other products it will take some time before you see your acne improving. Acne is an extremely common skin condition. During adolescence grease glands in the skin produce extra grease in response to normal amounts of sex hormones in your body and this can cause blocked pores (i.e. blackheads). When this happens the pores are invaded by bacteria. This produces chemicals which go into deeper parts of the skin to produce red spots filled with pus. In some people acne starts or continues after adolescence. BEFORE YOU USE ZINDACLIN _Is there any reason for not _ _being given Zindaclin? _ _ _ Make sure it is safe for you to use Zindaclin. _If you answer ‘YES’ to any of _ _the following questions, or you _ _are not sure, please tell your _ _doctor or pharmacist. _ • Pročitajte cijeli dokument
110919 Zindaclin PI v2 Page 1 of 7 ZINDACLIN: PRODUCT INFORMATION NAME OF THE DRUG: _ _ Clindamycin phosphate Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)- chloro-substitution of the 7(R)hydroxyl group and phosphorylation of the C(2)-OH group of the parent antibiotic lincomycin. It is a white to off-white, odourless, hygroscopic, crystalline powder, found to be soluble in water, slightly soluble in dehydrated alcohol, sparingly soluble in acetone, and practically insoluble in chloroform and ether. The chemical name for clindamycin phosphate is methyl 7-chloro-6,7,8-trideoxy -6-(1-methyl- _trans_-4-propyl- L -2-pyrrolidinecarboxamido)-1-thio- L -_threo_-(-D-_galacto_-octopyranoside-2-_O_- dihydrogen phosphate). It has a molecular weight of 504.96, and the molecular formula is C 18 H 34 ClN 2 0 8 PS OH OH O SCH 3 HO O OH H O H H H H H H C 3H 7 CH 3 N C NH CH 3 C C H H Cl H H O H P H CAS Number: 24729-96-2 DESCRIPTION:- White, translucent gel. 1g of gel contains 11.88mg clindamycin phosphate equivalent to 10.00mg clindamycin (1% w/w). Excipients: Propylene glycol, Purified water, Ethanol 96%, Zinc acetate dihydrate, Hydroxyethylcellulose, Sodium hydroxide 30% (w/w) PHARMACOLOGY:- _PHARMACODYNAMICS _ Pharmacotherapeutic group: Antiinfectives for treatment of acne ATC code: D10A F01 ZINDACLIN contains clindamycin phosphate which is hydrolysed in the skin to the active constituent clindamycin. Clindamycin is a lincosamide antibiotic with primarily bacteriostatic 110919 Zindaclin PI v2 Page 2 of 7 action against Gram positive aerobes and wide range of anaerobic bacteria . _In vitro_, Clindamycin MIC was 0.4 µg/mL against _P.acnes_. Cross resistance has been shown between clindamycin and erythromycin. When clindamycin phosphate is applied cutaneously, clindamycin is found in comedone samples at sufficient levels to be active aga Pročitajte cijeli dokument