Vytan Tablet 80mg

Država: Malezija

Jezik: engleski

Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivni sastojci:

VALSARTAN

Dostupno od:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

INN (International ime):

VALSARTAN

Jedinice u paketu:

30tablet Tablets; 100tablet Tablets

Proizveden od:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Uputa o lijeku

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
1
VYTAN TABLET
Valsartan (80mg, 160mg)
WHAT IS IN THIS LEAFLET
1.
What Vytan Tablet is used for
2.
How Vytan Tablet works
3.
Before you use Vytan Tablet
4.
How to use Vytan Tablet
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Vytan
Tablet
8.
Product Description
9.
Manufacturer
10.
Product Registration Holder
11.
Date of Revision
WHAT VYTAN TABLET IS USED FOR
Vytan is used
•
to treat high bloodpressure
•
to treat adult heart failure
patients.
•
to treat adults after a heart
attack
(myocardial
infarction)
to
improve
survival and reduce further
heartproblems.
HOW VYTAN TABLET WORKS
Vytan
belongs
to
a
class
of
medicines known as angiotensin-
II receptor antagonists, which help
to control high blood pressure.
Angiotensin
II
is
a
natural
substance in the body that causes
blood
vessels
to
tighten,
thus
causing
your
blood
pressure
to
increase.
Vytan
works
by
blocking the effect of angiotensin
II. As a result, blood vessels relax
and blood pressure is lowered.
If you have any question about
how
Vytan
works
or
why
this
medicine has been prescribed for
you, ask your doctor.
BEFORE YOU USE VYTAN TABLET
-
_When you must not use it _
_ _
Do not take Vytan:
•
If
you
have
ever
had
an
unusual or allergic reaction
to
Vytan
or
to
any
other
ingredients
of
this
product
listed
at
the
end
of
this
leaflet.
•
If
you are
pregnant or
are planning to get pregnant
If either of these apply to you, tell
your doctor without taking Vytan.
If you think you may be allergic,
ask your doctor for advice.
Take special care with Vytan:
•
If you have a liverdisease
•
If you have a serious kidney
disease
or
are
undergoing
dialysis
•
If you are already taking an
ACE-inhibitor together with a
beta
blocker
to
treat
your
heart failure
•
If
you
are
suffering
from
vomiting
or
diarrhea
or
are
taking high doses of a diuretic
(water pill).
•
If
you
are
suffering
from
heart
failure
or
have
experienced
a
heart
attack.
Follow
your
doctor's
instruction
for
the
starting
dose

Svojstava lijeka

L. DESCRIPTION
Vytan Tablet 80mg - A light pink round shape film-coated tablet,
slightly convex, scored at one side and
plain on the other side.
Vytan Tablet 160mg - A light orange oval shape film-coated tablet,
slightly convex, scored at one side and
plain on the other side.
LL. PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Angiotensin II Antagonists, plain, ATC
code: C09CA03
Valsartan is an orally active, potent, and specific angiotensin II
(Ang II) receptor antagonist. It acts
selectively on the AT1 receptor subtype, which is responsible for the
known actions of angiotensin II. The
increased plasma levels of Ang II following AT1 receptor blockade with
valsartan may stimulate the
unblocked AT2 receptor, which appears to counterbalance the effect of
the AT1 receptor.
Valsartan does not exhibit any partial agonist activity at the AT1
receptor and has much (about 20,000
fold) greater affinity for the AT1 receptor than for the AT2 receptor.
Valsartan is not known to bind to or
block other hormone receptors or ion channels known to be important in
cardiovascular regulation.
Valsartan does not inhibit ACE (also known as kininase II) which
converts Ang I to Ang II and degrades
bradykinin. Since there is no effect on ACE and no potentiation of
bradykinin or substance P, angiotensin
II antagonists are unlikely to be associated with coughing.
_Hypertension_
Administration of valsartan to patients with hypertension results in
reduction of blood pressure without
affecting pulse rate.
In most patients, after administration of a single oral dose, onset of
antihypertensive activity occurs within
2 hours, and the peak reduction of blood pressure is achieved within
4-6 hours. The antihypertensive
effect persists over 24 hours after dosing. During repeated dosing,
the antihypertensive effect is substan-
tially present within 2 weeks, and maximal effects are attained within
4 weeks and persist during
long-term therapy. Combined with hydrochlorothiazide, a significant
additional reduction in blood
pressure is