SODIUM CHLORIDE injection

Država: Sjedinjene Američke Države

Jezik: engleski

Izvor: NLM (National Library of Medicine)

Aktivni sastojci:

SODIUM CHLORIDE (UNII: 451W47IQ8X) (SODIUM CATION - UNII:LYR4M0NH37, CHLORIDE ION - UNII:Q32ZN48698)

Dostupno od:

Fresenius Kabi USA, LLC

INN (International ime):

SODIUM CHLORIDE

Sastav:

SODIUM CHLORIDE 234 mg in 1 mL

Administracija rute:

INTRAVENOUS

Tip recepta:

PRESCRIPTION DRUG

Terapijske indikacije:

Sodium Chloride Injection, USP, 23.4%, is indicated as an additive in parenteral fluid therapy for use in patients who have special problems of sodium electrolyte intake or excretion.  It is intended to meet the specific requirements of the patient with unusual fluid and electrolyte needs.  After available clinical and laboratory information is considered and correlated, the appropriate number of milliequivalents of sodium chloride required can be withdrawn from Sodium Chloride Injection, USP, 23.4% and diluted for use. Sodium Chloride Injection is indicated for the treatment of sodium, chloride and water deficiencies that commonly occur in many diseases.  Isotonic Sodium Chloride Injection should be limited to cases in which the chloride loss is greater than the sodium loss, as in vomiting from pyloric obstruction, or in which the loss is about equal, as in vomiting from duodenal, jejunal or ileal obstruction and in the replacement of aspirated gastrointestinal fluids. The toxic symptoms that follow various

Proizvod sažetak:

Sodium Chloride Injection, USP (4 mEq/mL) is supplied as follows: Product      No NDC No Volume 18730 63323-187-30        30 mL in a 30 mL vial These vials are Single Dose Vials; packaged 25 vials per tray. Preservative Free.  Discard unused portion. Use only if solution is clear and seal intact. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].

Status autorizacije:

unapproved drug other

Svojstava lijeka

SODIUM CHLORIDE- SODIUM CHLORIDE INJECTION
FRESENIUS KABI USA, LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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SODIUM CHLORIDE INJECTION USP
23.4%
4 MEQ/ML
CONCENTRATED
_FOR INTRAVENOUS USE_
_MUST BE DILTED PRIOR TO ADMINISTRATION_
DESCRIPTION
Sodium Chloride Injection, USP, 23.4%, is a concentrated, nonisotonic,
sterile, nonpyrogenic solution
of sodium chloride 234 mg in Water for Injection. pH adjusted with
sodium hydroxide or hydrochloric
acid if necessary. pH 4.5-7.0 when diluted to a concentration of 0.9%.
8008 mOsmol/L.
Sodium chloride is an electrolyte replenisher. It occurs as colorless
cubic crystals or white crystalline
powder and has a saline taste. Sodium chloride is freely soluble in
water; it is soluble in glycerin and
slightly soluble in alcohol.
The empirical formula for sodium chloride is NaCl and the molecular
weight is 58.44.
CLINICAL PHARMACOLOGY
Sodium chloride comprises over 90% of the inorganic constituents of
the blood serum. Both its ions
are physiologically important. Sodium, more than any other ion,
determines the osmotic pressure of
interstitial fluids and the degree of hydration of tissues. When the
intake of the chloride ion is less than
is excreted, there is a relative increase in the blood bicarbonate
level, producing the condition known as
alkalosis. Other symptoms of sodium chloride deficiency are nausea,
vomiting and increased irritability
of muscles, evidenced by cramps and, possibly, convulsions. It is well
known that excessive sweating
will cause ‘‘heatcramps,’’ i.e., muscle cramps in the abdomen
and extremities, which can be completely
relieved only by ingestion of a weak salt solution.
Approximately 25% of the total body sodium is found in the bone. The
regulation of salt and water
metabolism is governed by different mechanisms; however, changes in
the intake, distribution and output
of salt are, in health, associat