MENTOPIN ACETYLCYSTEINE 600 EFFERVESCENT TABLET

Država: Malezija

Jezik: engleski

Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivni sastojci:

Acetylcysteine

Dostupno od:

Medicell Pharmaceutical(malaysia) Sdn.bhd

INN (International ime):

Acetylcysteine

Jedinice u paketu:

5 x 2's tablet Tablets; 10 x 2's tablet Tablets

Proizveden od:

Hermes Pharma GmbH

Uputa o lijeku

_Consumer Medication Information Leaflet (RiMUP)_
MENTOPIN ACETYLCYSTEINE 600
EFFERVESCENT TABLET
Acetylcysteine (600mg)
WHAT IS IN THIS LEAFLET
1.
What Mentopin is used for
2.
How Mentopin works
3.
Before you use Mentopin
4.
How to use Mentopin
5.
While you are using
Mentopin
6.
Side effects
7.
Storage & disposal of
Mentopin
8.
Product description
9.
Manufacturer and Product
Registration Holder
10.
Date of Revision
WHAT MENTOPIN IS USED FOR
Treatment of respiratory
affections characterized by thick
& viscous hypersecretions:
Acute bronchitis, chronic
bronchitis and its exacerbations,
pulmonary emphysema,
mucoviscidosis & bronchiectasis.
HOW MENTOPIN WORKS
Mentopin works by making
mucus (phlegm) less sticky. This
makes the mucus easier to cough
out.
BEFORE YOU USE MENTOPIN
-
_When you must not use it_
Do not take Mentopin tablets if
you are:

allergic (hypersensitive) to
acetylcysteine or any of the
other ingredients of Mentopin
tablet _(see ingredient list)_
If you have these conditions, do
not take this medicine and inform
your doctor.
-
_Before you start to use it_
Inform your doctor if you have
any of the following conditions:

asthma

gastric ulcer
-
_Taking other medicines_
You should always tell your doctor
if you are taking or have recently
taken any other medicines
including those obtained without a
prescription.
HOW TO USE MENTOPIN
-
_How much to use_
Adult and adolescent (over 14 years
old) dose:

600mg daily as a single dose
-
_When to use it_
It is important that you take
Mentopin exactly as your doctor
has instructed.
Dissolve content of an
effervescent tablet in a glass of
water and drink immediately.
-
_How long to use it_
Take Mentopin tablets for the
duration of time your doctor
recommends.
-
_If you forget to use it_
If you miss a dose, do not try to
make up for it by doubling up on
the next dose. Just take the next
dose at the usual time. Consult
your doctor or pharmacist if you
have any doubts.
_- If you use too much (overdose)_
If you accidentally take an
overdose of Mentopin, co

Svojstava lijeka

MENTOPIN®
ACETYLCYSTEINE 600
EFFERVESCENT TABLET
BRAND OR PRODUCT NAME
Mentopin Acetylcysteine 600mg Effervescent
Tablet
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
Mentopin Acetylcysteine 600mg Effervescent
Tablet contains 600mg acetylcysteine.
PRODUCT DESCRIPTION
Round, white tablets with a smooth and faultless
surface and a break-mark on one side.
PHARMACODYNAMICS
Pharmacotherapeutic group: mucolytics
ATC code: R05CB01
Mechanism of action
Acetylcysteine is a derivative of the amino acid
cysteine. Acetylcysteine has a secretolytic and
secretomotoric effect in the area of the bronchial
tract. It is discussed that acetylcysteine breaks
the disulfide bonds between the
mucopolysaccharide fibres and has a
depolymerising effect on
DNA fibres (in purulent mucus). This mechanism is
thought to decrease the viscosity of the mucus.
An alternative mechanism of acetylcysteine is
meant to be based on the ability of its reactive SH
group to bind - and hence detoxify - chemical
radicals.
Furthermore, acetylcysteine contributes to an
increased glutathione synthesis, which is
important for the detoxification of noxae. This
explains its effect as an antidote in paracetamol
intoxication.
A protective effect on the frequency and severity
of bacterial exacerbations in patients with chronic
bronchitis/cystic fibrosis has been described when
acetylcysteine is given prophylactically.
PHARMACOKINETICS
Following oral administration, acetylcysteine is
rapidly and almost completely absorbed and
metabolized in the liver to cysteine, the
pharmacologically active metabolite, as well as
diacetylcystine, cystine and other mixed disulfides.
Due to the high first-pass effect, the bioavailability
of orally administered acetylcysteine is very low
(approx. 10 %). In humans, maximum plasma
concentrations are reached after 1 - 3 hours,
whereby the maximum plasma concentration of
the metabolite cysteine is in the range of approx. 2
μmol/l. Protein binding of acetylcysteine has been
determined to be approx. 50 %.
Acetylcysteine and its metabolites occur