KAMPIBIOTIC 500 Injection

Država: Malezija

Jezik: engleski

Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivni sastojci:

AMPICILLIN SODIUM

Dostupno od:

AVERROES PHARMACEUTICALS SDN. BHD.

INN (International ime):

AMPICILLIN SODIUM

Jedinice u paketu:

0.5gm mcg/mL; 50 Units Units; 0 gm 10 Units Units

Proizveden od:

KARNATAKA ANTIBIOTICS & PHARM LTD

Uputa o lijeku

Not Applicable

Svojstava lijeka

KAMPIBIOTIC 500 INJECTION
AMPICILLIN 500 MG
PRODUCT NAME
KAMPIBIOTIC 500 Injection
PRODUCT DESCRIPTION
White powder in glass vials.
COMPOSITION
Each vial contains Ampicillin sodium BP equivalent to Ampicillin 500
mg
PHARMACODYNAMICS
Ampicillin exerts its action on growing and dividing bacteria by
inhibiting bacterial cell
wall synthesis. Benzylpenicillin inhibits the final cross-linking
stage of peptidoglycan
production by binding to and inactivating transpeptidases
(penicillin-binding protein on
the surface of the bacterial cell membrane) causing the cell wall to
rupture by osmotic
pressure. It is now realised that other earlier stages in cell-wall
synthesis can also be
inhibited by Ampicillin.
_PHARMACOLOGICAL ACTION_
Ampicillin is bactericidal for both Gram-positive and Gram-negative
organisms.
_Gram-Positive _
_Organisms: _
Ampicillin
is
active
against
_Strep. _
_Pyogenes, _
_Strep. _
_Pneumoniae _
and
_Strep. Viridans_
. Pneumococcal strains which are relatively resistant to
penicillin
G
are
more
sensitive
to
Ampicillin.
Group
B
Streptococci
are
always
Ampicillin sensitivite, in addition Ampicillin combines with
aminoglycosides such as
Kanamycin,
gentamicin,
tobramycin
or
amikacin
acts
synergistically
against
these
organisms resulting in accelerated streptococcal killing.
_Strep. faecalis _
is usually sensitive to Ampicillin and often more so than penicillin
G. The
combination of ampicillin with streptomycin or kanamycin is
synergistic against 50-75%
of
_Strep. faecalis_
, whereas Ampicillin plus gentamicin or tobramycin is synergistic
against
nearly
all
such
strains.
Anaerobic
Gram-positive
cocci
such
as
peptococcus
and
peptostreptococcus
spp.
and
anaerobic
streptococci
are
nearly
always
Ampicillin
sensitive.
Ampicillin is destroyed by staphylococcal beta lactamase, so that most
_Staph. aureus _
and
hospital acquired
_Staph. epidermidis _
are Ampicillin resistant.
_Staph. saprophyticus _
and
other coagulase negative staphylococci such as
_Staph. hominis _
and haemolyticus which
may be urethral isolates of y