HYOSCYAMINE SULFATE elixir

Država: Sjedinjene Američke Države

Jezik: engleski

Izvor: NLM (National Library of Medicine)

Aktivni sastojci:

HYOSCYAMINE SULFATE (UNII: F2R8V82B84) (HYOSCYAMINE - UNII:PX44XO846X)

Dostupno od:

Method Pharmaceuticals, LLC

INN (International ime):

HYOSCYAMINE SULFATE

Sastav:

HYOSCYAMINE SULFATE 0.125 mg in 5 mL

Tip recepta:

PRESCRIPTION DRUG

Status autorizacije:

unapproved drug other

Svojstava lijeka

HYOSCYAMINE SULFATE- HYOSCYAMINE SULFATE ELIXIR
METHOD PHARMACEUTICALS, LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
----------
HYOSCYAMINE SULFATE ELIXIR
(HYOSCYAMINE SULFATE ORAL SOLUTION)
Rx Only
DESCRIPTION:
Hyoscyamine Sulfate Elixir (hyoscyamine sulfate oral solution USP)
contains 0.125 mg hyoscyamine
sulfate per 5 mL with 20% v/v alcohol for oral administration.
Hyoscyamine sulfate is one of the principal
anticholinergic/antispasmodic components of belladonna
alkaloids. The empirical formula is (C17H23NO3)2•H2SO4• 2H2O and
the molecular weight is 712.85.
Chemically, it is benzeneacetic acid, (a-(hydroxymethyl))-,
8-methyl-8- azabicyclo[3.2.1.]oct-3-yl ester,
[3(S)-endo]-, sulfate (2:1), dihydrate with the following structure:
Hyoscyamine Sulfate Elixir also contains the inactive ingredients:
Alcohol, Citric Acid, D&C Yellow
# 10, FD&C Red # 40, Glycerin, Orange Flavor, Purified Water,
Sorbitol, and Sucrose.
CLINICAL PHARMACOLOGY:
Hyoscyamine sulfate inhibits specifically the actions of acetylcholine
on structures innervated by
postganglionic cholinergic nerves and on smooth muscles that respond
to acetylcholine but lack
cholinergic innervation. These peripheral cholinergic receptors are
present in the autonomic effector
cells of the smooth muscle, cardiac muscle, the sinoatrial node, the
atrioventricular node, and the
exocrine glands. At therapeutic doses, it is completely devoid of any
action on autonomic ganglia.
Hyoscyamine sulfate inhibits gastrointestinal propulsive motility and
decreases gastric acid secretion.
Hyoscyamine sulfate also controls excessive pharyngeal, tracheal and
bronchial secretions.
Hyoscyamine sulfate is absorbed totally and completely by oral
administration. Once absorbed,
hyoscyamine sulfate disappears rapidly from the blood and is
distributed throughout the entire body.
The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. Hyosc