Država: Sjedinjene Američke Države
Jezik: engleski
Izvor: NLM (National Library of Medicine)
PHENYLBUTAZONE (UNII: GN5P7K3T8S) (PHENYLBUTAZONE - UNII:GN5P7K3T8S)
A&G Pharmaceuticals
PHENYLBUTAZONE
PHENYLBUTAZONE 1 g in 10 g
ORAL
PRESCRIPTION
Phenylbutazone is for the relief of inflammatory conditions associated with the musculoskeletal system in horses. In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy should be used concurrently. Use with caution in patients who have a history of drug allergy.
Phenylbutazone Powder is supplied in 1.1 lb (0.5 kg) jars and 2.2 lb (1 kg) jars each containing a dispensing scoop. One level scoop delivers 10 grams of powder containing 1 gram of phenylbutazone.
Abbreviated New Animal Drug Application
EQUIZONE 50/100- PHENYLBUTAZONE POWDER A&G PHARMACEUTICALS ---------- EQUIZONE 50/100 (PHENYLBUTAZONE) POWDER (phenylbutazone) Powder FOR ORAL USE IN HORSES ONLY NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits the extralabel use of this product in female dairy cattle 20 months of age or older. DESCRIPTION Phenylbutazone chemically is 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione. C H N O Mol. Wt. 308.38 Each 10 grams of powder contains 1 gram phenylbutazone INDICATIONS Phenylbutazone is for the relief of inflammatory conditions associated with the musculoskeletal system in horses. In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy should be used concurrently. DOSAGE AND ADMINISTRATION For Horses Only: Administer orally (using the 0.6 ounce (18 mL) scoop provided) on a small amount of palatable feed and mix well. Give 1 to 2 level scoops per 500 pounds of body weight, but do not exceed 4 scoops per animal daily. Use the high dose for the first 48 hours, then gradually reduce to a maintenance dose. CONTRAINDICATIONS Use with caution in patients who have a history of drug allergy. WARNING Do not use in horses intended for human consumption. 19 20 2 2 HUMAN WARNING Keep this and all medications out of the reach of children. Dispense in tight, child resistant containers. PRECAUTION Concomitant use with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided or closely monitored. CLINICAL PHARMACOLOGY Phenylbutazone was first synthesized in 1948 and introduced into human medicine in 1949. Kuzell (1), (2), (3), Payne (4), Fleming (5) and Denko (6) demonstrated the clinical effectiveness of phenylbutazone in gout, gouty arthritis, acute arthritis, acute rheumatism and various other rheumatoid disorders in humans. Fabre (7), Domenjoz (8), Wilhelmi (9) and Yourish (10) have established the anti-rheumatic and anti- inflammatory activit Pročitajte cijeli dokument