Država: Malezija
Jezik: engleski
Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
COLCHICINE
DYNAPHARM (M) SDN BHD
COLCHICINE
100 Tablets; 100 Tablets
DYNAPHARM (M) SDN BHD
Consumer Medication Information Leaflet (RiMUP) DYNA COLCHICINE TABLET 0.5MG Colchicine (0.5 mg) Page 1 of 2 What is in this leaflet 1. What DYNA COLCHICINE TABLET 0.5MG is used for 2. How DYNA COLCHICINE TABLET 0.5MG works 3. Before you use DYNA COLCHICINE TABLET 0.5MG 4. How to use DYNA COLCHICINE TABLET 0.5MG 5. While you are using it 6. Side effects 7. Storage and Disposal of DYNA COLCHICINE TABLET 0.5MG 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision What DYNA COLCHICINE TABLET 0.5MG is used for DYNA COLCHICINE TABLET 0.5MG is used for the relief of acute gout when the dramatic response can be diagnostic. It is also used for the prevention of recurrent gout and to prevent acute attacks during the first few months of treatment with Allopurinol or gout suppressants. How DYNA COLCHICINE TABLET 0.5MG works Colchicine produces a dramatic response in acute gout probably by reducing the inflammatory reaction to urate crystals. Colchicine also inhibits cell division. Before you use DYNA COLCHICINE TABLET 0.5MG - When you must not use it Pregnancy and lactation Do not take DYNA COLCHICINE TABLET 0.5MG if you are pregnant, trying to get pregnant or think you may be pregnant. Do not take DYNA COLCHICINE TABLET 0.5MG if you are breast- feeding. Ask your doctor or pharmacist for advice before taking any medicine. - Before you start use it Tell your doctor if you have: • Hypersensitivity to the active substance or to any of the excipients. • Blood dyscrasias. • Pregnancy. • Breastfeeding. • Childbearing potential unless using effective contraceptive measures. • Severe renal impairment. • Severe hepatic impairment. • Undergoing haemodialysis. • Renal or hepatic impairment who are taking a P-glycoprotein (P-gp) inhibitor or a strong CYP3A4 inhibitor. - Taking other medicines Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Potential risk of severe drug inter Pročitajte cijeli dokument
DYNA COLCHICINE TABLET 0.5MG MAL19962516AZ DESCRIPTION: TABLET Colour : White Shape : Round/Biconvex Coating : Film-coated EACH TABLET CONTAINS: Colchicine ..................... 0.5 mg PHARMACODYNAMICS: Colchicine produces a dramatic response in acute gout probably by reducing the inflammatory reaction to urate crystals; this effect might be due to several actions including decreased leucocyte mobility. It is not an analgesic and has no effect on blood concentrations of Uric Acid, or on the excretion of Uric Acid. Colchicine also has an antimitotic action. PHARMACOKINETICS: Colchicine is readily absorbed from the gastrointestinal tract and reaches peak concentration in the plasma within 2 hours. It is partially deacetylated in the liver and the unchanged drug and its metabolites are excreted in the bile and undergo intestinal reabsorption. Colchicine is found in high concentrations in leucocytes, kidneys, the liver, and spleen. Most of the drug is excreted in the faeces but 10 to 20% is excreted in the urine and this proportion rises in patients with liver disorders. INDICATION: It is used for the relief of acute gout when the dramatic response can be diagnostic. It is also used for the prophylaxis of recurrent gout and to prevent acute attacks during the first few months of treatment with Allopurinol or uricosurics. RECOMMENDED DOSE: Treatment of acute gout attack: 1 mg (2 tablets) to start followed by 500 micrograms (1 tablet) after 1 hour. No further tablets should be taken for 12 hours. After 12 hours, treatment can resume if necessary with a maximum dose of 500 micrograms (1 tablet) every 8 hours until symptoms are relieved. The course of treatment should end when symptoms are relieved or when a total of 6 mg (12 tablets) has been taken. No more than 6 mg (12 tablets) should be taken as a course of treatment. After completion of a course, another course should not be started for at least 3 days (72 hours). Prophylaxis of gout attack during initiation of therapy with allopurinol and uricosuric drugs: 500 micr Pročitajte cijeli dokument