DIMAX MR TABLETS 30MG

Država: Malezija

Jezik: engleski

Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivni sastojci:

GLICLAZIDE

Dostupno od:

AVERROES PHARMACEUTICALS SDN. BHD.

INN (International ime):

GLICLAZIDE

Jedinice u paketu:

100tablet Tablets

Proizveden od:

SIU GUAN CHEM. IND.CO.,LTD.

Svojstava lijeka

DIMAX MR TABLET 30MG
GLICLAZIDE 30MG (MODIFIED RELEASE TABLET)
DESCRIPTION
Dimax MR tablets 30mg are white, round tablets and the surface of the
tablet are and
COMPOSITION
Each tablet contains 30mg of Gliclazide.
ACTION
SULFONAMIDES, UREA DERIVATIVES
ATC code: A10BB09
Gliclazide
is
a
hypoglycaemic
sulphonylurea
oral
antidiabetic
active
substance
differing
from
other
related
compounds by an N-containing heterocyclic ring with an endocyclic
bond.
Gliclazide reduces blood glucose levels by stimulating insulin
secretion from the β-cells of the islets of Langerhans.
Increase in postprandial insulin and C-peptide secretion persists
after two years of treatment.
In addition to these metabolic properties, gliclazide has
haemovascular properties.
SUMMARY OF PHARMACODYNAMICS AND PHARMACOKINETICS
Gliclazide is readily absorbed from the gastrointestinal tract and
extensively bound to plasma proteins. The half-life is
about 10 to 12 hours. Gliclazide is extensively metabolized in the
liver to metabolites that have no significant
hypoglycemic activity. Metabolites and a small amount of unchanged
drug are excreted in the urine.
INDICATIONS
Gliclazide is indicated for the treatment of non insulin-dependent
diabetes (type 2) in adults when dietary measures,
physical exercise and weight loss alone are not sufficient to control
blood glucose.
ADVERSE REACTIONS/SIDE EFFECTS
Gastrointestinal disturbances such as nausea, vomiting, heartburn,
anorexia, diarrhea and metallic taste may occur with
Gliclazide and are usually mild and dose dependent; increased appetite
and weight gain may occur. Skin rashes and
pruritus and photosensitivity have been reported. Rashes are usually
hypersensitivity reactions and may progress to
more serious disorders. Other severe effects maybe manifestations of
hypersensitivity reaction. They include altered
liver
enzyme
values,
hepatitis
and
cholestatic
jaundice,
leucopenia,
thrombocytopenia,
aplastic
anemia,
agranulocytosis, haemolytic anemia, erythema multiforme or the
Stevens-Johnson syndrome, exfoliativ