DICLOXACILLIN SODIUM capsule

Država: Sjedinjene Američke Države

Jezik: engleski

Izvor: NLM (National Library of Medicine)

Aktivni sastojci:

DICLOXACILLIN SODIUM (UNII: 4HZT2V9KX0) (DICLOXACILLIN - UNII:COF19H7WBK)

Dostupno od:

Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC

INN (International ime):

DICLOXACILLIN SODIUM

Sastav:

DICLOXACILLIN 500 mg

Tip recepta:

PRESCRIPTION DRUG

Status autorizacije:

Abbreviated New Drug Application

Svojstava lijeka

DICLOXACILLIN SODIUM- DICLOXACILLIN SODIUM CAPSULE
LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC
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DICLOXACILLIN SODIUM CAPSULES USP
3123
3125
RX ONLY
To reduce the development of drug resistant bacteria and maintain the
effectiveness of dicloxacillin
sodium capsules USP and other antibacterial drugs, dicloxacillin
sodium capsules USP should be used
only to treat or prevent infections that are proven or strongly
suspected to be caused by bacteria.
DESCRIPTION
Dicloxacillin sodium is a semisynthetic antibiotic substance which
resists destruction by the enzyme
penicillinase(beta - lactamase). It is monosodium
(2_S_,5_R_,6_R_)-6-[3-(2,6-dichlorophenyl)- 5-methyl-4-
isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0]heptane-2-carboxylate
monohydrate.
Dicloxacillin is administered orally via capsule form or powder for
reconstitution. Structurally,
dicloxacillin sodium may be represented as follows:
C
H Cl
N NaO S·H O MW 510.32
INACTIVE INGREDIENTS
Capsules
Magnesium Stearate.
Capsule Shell and Print Constituents
D&C Yellow #10 Aluminum Lake, FD&C Blue #1 Aluminum Lake, FD&C Blue #2
Aluminum Lake,
FD&C Red #40 Aluminum Lake, Gelatin, Pharmaceutical Glaze, Silicon
Dioxide, Sodium Lauryl
Sulfate, Synthetic Black Iron Oxide, Titanium Dioxide and may contain
Carboxymethylcellulose Sodium
and/or Propylene Glycol.
CLINICAL PHARMACOLOGY
MICROBIOLOGY
Dicloxacillin exerts a bactericidal action against
penicillin-susceptible microorganisms during the state
of active multiplication. All penicillins inhibit the biosynthesis of
the bacterial cell wall.
The drugs in this class are highly resistant to inactivation by
staphylococcal penicillinase and are active
19
16
2
3
5
2
against penicillinase-producing and nonpenicillinase-producing strains
of _Staphylococcus aureus. _The
penicillinase- resistant penicillins are active _in vitro _against a
variety of other bacteria.
SUSCEPTIBILITY PLATE TESTING
Quantitative methods of susceptibility testing that require
measurements of zone diameters