Curekuf W Cough Syrup

Država: Malezija

Jezik: engleski

Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivni sastojci:

DIPHENHYDRAMINE HYDROCHLORIDE; AMMONIUM CHLORIDE

Dostupno od:

SM PHARMACEUTICALS SDN. BHD.

INN (International ime):

DIPHENHYDRAMINE HYDROCHLORIDE; AMMONIUM CHLORIDE

Jedinice u paketu:

100 ml

Proizveden od:

SM PHARMACEUTICALS SDN. BHD.

Uputa o lijeku

Consumer Medication Information Leaflet (RiMUP)
Curekuf W Cough Syrup
EACH 5ML CONTAINS Diphenhydramine Hydrochloride 14.0 mg and Ammonium
Chloride 135.0 mg
_______________________________________________________________________________________________
__________________________________________________________________________________________________
1
WHAT IN THIS LEAFLET
1. What is Curekuf W used for
2.How Curekuf W works
3.Before you use Curekuf W
4.How to take Curekuf W
5.While you are using it
6.Side Effects
7. Storage and Disposal of Curekuf W
8.Products Descriptions
9.Manufacturer and Product
Registration Holder
10.Date of revision
11.Serial No.
WHAT IS CUREKUF W USED FOR
It is indicated as an expectorant for
control of coughs due to colds or allergy.
HOW CUREKUF W WORKS
Diphenhydramine Hydrochloride is an
antihistamine that works by blocking a
certain natural substance (histamine) that
your body makes during an allergic
reaction.
Ammonium chloride acts by reflexing
and irritating the gastric layer.
These increases the volume of secretions
in the respiratory tract; reduce thickness
of phlegm which presumably is easier
to cough up.
BEFORE YOU USE CUREKUF W
_-When you must not use it _
Do not use Curekuf W if you
• are allergic to any ingredients in this
medicine.
• not to be used in children less than
2 years of age.
_-Before you start to use it _
Tell your doctor or pharmacist before
using Curekuf W if you:
• are pregnant or plan to get pregnant.
• are breast-feeding or plan to start
breast-feeding.
_ _
_ _
_ _
_-Taking other medicine _
Tell your doctor or pharmacist if you
are taking any other medicines,
including any that you buy without
a prescription from a pharmacy,
supermarket or health food shop. Inform
your doctor or pharmacist if you are taking:
•
Alcohol
•
Tranquilizers (a medicinal drug taken
to reduce tension or anxiety).
•
Sedative hypnotics (a class
of drugs used to induce and/or
maintain sleep).
•
CNS depressant (medicines that
include sedatives, tranquilizers,
and hypnotics).

Svojstava lijeka

SM PHARMACEUTICALS SDN BHD
CUREKUF W COUGH SYRUP
DESCRIPTION:
A brown colored, syrupy liquid with honey and pleasantly flavored with
peach and raspberry flavour.
COMPOSITION:
Each 5 ml contains:
1. Diphenhydramine Hydrochloride 14.0 mg
2. Ammonium Chloride 135.0 mg
Preservative:
Sodium Benzoate 7.5mg
PHARMACODYNAMICS:
Diphenhydramine suppresses the cough reflex by a direct effect on the
cough centre in the medulla of the brain. Its antihistaminic action is
by
competing with histamine for H1-receptor sites on effector cells. The
antimuscarinic actions of antihistamine provides a drying effect on
the
nasal
mucosa.
It
diminishes
vestibular
stimulation
and
depress
labyrinthine function. An action on the medullary chemoreceptive
trigger
zone may also be involved in the antiemetic effect.
Ammonium Chloride has irritant action on the gastric mucous membrane
and may contribute expectorant action.
PHARMACOKINETICS:
Diphenhydramine is readily absorbed from the GIT. It is metabolised in
the liver and excreted mainly as metabolites in the urine. After an
oral
dose of 50 mg of Diphenhydramine HCl, plasma concentrations of 50 to
54 ng/ml are attained at 1 hour; at 2 hours, plasma concentration is
64 to
70 ng/ml. The plasma half-life after an oral dose is 13 to 21 hours.
98%
is bound to plasma proteins. About 50% of an oral dose is metabolised
in
the liver before reaching the general circulation. Reactions include
N-
deakylation and deamination. In the urine, up to 3% of a dose is
excreted
unchanged, up to 13% as basic amines and up to 65% as diphenylmethane
metabolites.
The
major
urinary
metabolite
appears
to
be
diphenylmethoxyacetic acid in free or conjugated form.
Ammonium Chloride is rapidly absorbed from the GIT. The Ammonium
is converted into urea in the liver. The anion thus is liberated into
the
blood stream and extracellular fluids causes a metabolic acidosis and
decreases the pH of the urine. This is followed by transient diuresis.
INDICATIONS:
It is indicated as an expectorant for control of coughs due to colds
or
al