BENZAPEN 2.4 miu Injection

Država: Malezija

Jezik: engleski

Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivni sastojci:

BENZATHINE PENICILLIN

Dostupno od:

AVERROES PHARMACEUTICALS SDN. BHD.

INN (International ime):

BENZATHINE PENICILLIN

Jedinice u paketu:

50Units Units; 10 Units Units

Proizveden od:

KARNATAKA ANTIBIOTICS & PHARM LTD

Uputa o lijeku

NOT APPLICABLE

Svojstava lijeka

BENZAPEN 2.4 MIU INJECTION
STERILE PENICILLIN G BENZATHINE 1.8 G (2,400,000 UNITS)
PRODUCT NAME
BENZAPEN 2.4 miu Injection
PRODUCT DESCRIPTION
A white powder (for injection) in glass vials.
COMPOSITION
Each vial contains Sterile Penicillin G Benzathine 1.8 g (2,400,000
Units).
PHARMACODYNAMIC
Benzathine penicillin is a depot preparation of benzylpenicillin with
the same mode of
action
as
that
benzylpenicillin.
The
penicillin
nucleus
consist
of
thiazolidine
ring
connected to β-lactam ring to which is attached a side chain. The
β-lactam ring plays an
important role in the antibacterial activity of β-lactam antibiotics.
It can be opened by β-
lactamase produced by enzyme-producing organisms. As soon as the
β-lactam ring is
opened
by the
β-lactamase
the
hydrolysed
penicillin
is
inactivated.
The
side-chain
determines most of the pharmacological properties as well as the
characteristics of the
antimicrobial activity penicillins. Penicillin kills bacteria by
interfering with the synthesis
of the bacteria cell wall. This is composed of peptidoglycan which is
a heteropolymeric
structure that provides the cell wall with mechanical stability. The
final stage in the
synthesis of peptidoglycan involves the completion of the
cross-linking between the
terminal
glycine
residue
of
the
pentaglycine
bridge
and
the
fourth
residue
of
the
pentapeptide (d-alanine).
The transpeptidase that
performs
this
step
is
inhibited
by
penicillins and cephalosphorins, the β-lactam ring of which acts as
an analogue of acyl-d-
ananyl-d-alanine. As a result the bacteria cell wall is weakened and
then ruptures. Recently
it was proved that there are penicillin-binding-proteins (PBPs) in the
cell
envelope of
bacteria which are the targets for β-lactam antibiotics.
PHARMACOKINETICS
_Absorption and serum levels_
Benzathine penicillin is stable in the presence of gastric juice, but
not absorption from the
gastro-intestinal tract. Benzathine penicillin is very slowly absorbed
from intramuscular
deport. It is hydrolysed to benzylpenicillin and produce