Država: Australija
Jezik: engleski
Izvor: Department of Health (Therapeutic Goods Administration)
metformin hydrochloride
Cipla Australia Pty Ltd
Metformin hydrochloride
Registered
APO-METFORMIN 500/850/1000 _Contains the active ingredient metformin (met-FOR-min) hydrochloride_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about metformin It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist or diabetes educator. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is APO- Metformin 500, 850 or 1000 tablets. It contains the active ingredient metformin (as metformin hydrochloride). It is used to treat type 2 diabetes (also called non-insulin dependent diabetes mellitus or maturity onset diabetes) in adults and children over 10 years of age. It is especially useful in those who are overweight, when diet and exercise are not enough to lower high blood glucose levels (hyperglycaemia). For adult patients, metformin can be used alone, or in combination with other oral diabetic medicines or in combination with insulin in insulin requiring type 2 diabetes. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's Pročitajte cijeli dokument
Product Information – Australia APO-Metformin 500/850/1000 Tablets Page 1 APO-METFORMIN 500 TABLETS APO-METFORMIN 850 TABLETS APO-METFORMIN 1000 TABLETS NAME OF THE MEDICINE Metformin hydrochloride. Chemical Name: 1,1-dimethylbiguanide hydrochloride Structural Formula: N H 2 N H N CH 3 CH 3 NH NH , HCl Molecular Formula: C 4 H 11 N 5 .HCl Molecular Weight: 165.6 CAS Registry No: 1115-70-4 DESCRIPTION Metformin hydrochloride is a white, crystalline powder which is almost odourless and hygroscopic. It is freely soluble in water, slightly soluble in ethanol (96%) and practically insoluble in chloroform and in ether. PHARMACOLOGY Metformin is an oral biguanide hypoglycaemic agent. It causes an increased peripheral uptake of glucose by increasing the biological efficiency of available exogenous or endogenous insulin. The mode of action of metformin may be linked to an increase of insulin sensitivity. It does not stimulate insulin release but does require the presence of insulin to exert its anti-hyperglycaemic effect. Possible mechanisms of action include inhibition of gluconeogenesis in the liver, delay in glucose absorption from the gastrointestinal tract and an increase in peripheral uptake of glucose. Metformin has an antiketogenic activity which is comparable, though somewhat inferior, to insulin itself. Metformin lowers both basal and post-prandial blood glucose in diabetic patients but does not cause hypoglycaemia in either diabetics or normal individuals. PHARMACOKINETICS Absorption After oral administration, metformin hydrochloride is absorbed along the entire gastrointestinal mucosa. Studies using single oral doses of metformin tablets indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption of meformin rather than an increase in elimination. After oral administration, metformin absorption is saturable and incomplete. It is assumed that the pharmacokinetics of metformin absorption are non-linear. At usual clinical doses and dosing schedules of metfor Pročitajte cijeli dokument