Država: Australija
Jezik: engleski
Izvor: Department of Health (Therapeutic Goods Administration)
lercanidipine hydrochloride
Apotex Pty Ltd
Lercanidipine hydrochloride
Registered
APO-LERCANIDIPINE TABLETS _Contains the active ingredient, lercanidipine (as lercanidipine hydrochloride)_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some of the common questions about lercanidipine. It does not contain all the available information. It does not replace seeking advice from your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor has weighed the risks of you taking lercanidipine against the benefits this medicine is expected to have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with the medicine. You may need to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is APO- Lercanidipine. It contains the active ingredient, lercanidipine (as lercanidipine hydrochloride). Lercanidipine belongs to a group of medicines called dihydropyridine calcium channel blockers. Lercanidipine helps lower high blood pressure, otherwise known as hypertension. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ This medicine works by relaxing some of the blood vessels in the body and reducing resistance to the flow of blood through the blood vessels. Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. If your blood pressure stays higher than is needed, even when you are calm and relaxed, you have hypertension (high blood pressure). There are usually no symptoms of hyperten Pročitajte cijeli dokument
Product Information – Australia APO- Lercanidipine Tablets Page 1 APO-LERCANIDIPINE TABLETS NAME OF THE MEDICINE Lercanidipine Hydrochloride. Chemical Name: 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-2-[(3,3- diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride. Structural Formula: HCl Molecular Formula: C 36 H 42 ClN 3 O 6 Molecular Weight: 648.2 (free base: 611.7) CAS Registry Number: 132866-11-6 DESCRIPTION Lercanidipine is a dihydropyridine derivative. It is a racemate due to the presence of a chiral carbon atom at position 4 of the 1,4-dihydropyridine ring. Lercanidipine hydrochloride is a yellow amorphous powder, readily soluble in chloroform and methanol, practically insoluble in water. Octanol:water partition coefficient (LogP): 6.4. Each tablet contains 10 mg or 20 mg lercanidipine hydrochloride as the active ingredient. In addition, each tablet contains the following inactive ingredients: Cellulose – microcrystalline , lactose monohydrate, croscarmellose sodium, butylated hydroxytoluene, magnesium stearate, hypromellose, macrogol 8000, titanium dioxide, purified talc, yellow iron oxide (10 mg only) and red iron oxide (20 mg only). ` PHARMACOLOGY PHARMACOLOGICAL ACTIONS Lercanidipine is a calcium antagonist of the dihydropyridine group and selectively inhibits the transmembrane influx of calcium into cardiac and vascular smooth muscle, with a greater effect on vascular smooth muscle than on cardiac smooth muscle. The antihypertensive action is due to a direct relaxant effect on vascular smooth muscle which lowers total peripheral resistance and hence blood pressure. Lercanidipine has a prolonged antihypertensive activity because of its high membrane partition coefficient. It is devoid of negative inotropic effects and its vascular selectivity is due to its voltage dependent calcium antagonist activity. Since the vasodilatation induced by lercanidipine hydrochloride is gradual in onset, acute hypotension with reflex tachycardia has rarely been observ Pročitajte cijeli dokument