AMILORIDE HYDROCLORIDE tablet

Država: Sjedinjene Američke Države

Jezik: engleski

Izvor: NLM (National Library of Medicine)

Aktivni sastojci:

AMILORIDE HYDROCHLORIDE (UNII: FZJ37245UC) (AMILORIDE - UNII:7DZO8EB0Z3)

Dostupno od:

KAISER FOUNDATION HOSPITALS

INN (International ime):

AMILORIDE HYDROCHLORIDE

Sastav:

AMILORIDE HYDROCHLORIDE ANHYDROUS 5 mg

Tip recepta:

PRESCRIPTION DRUG

Status autorizacije:

New Drug Application

Svojstava lijeka

AMILORIDE HYDROCLORIDE- AMILORIDE HYDROCLORIDE TABLET
KAISER FOUNDATION HOSPITALS
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AMILORIDEHCL TABLETS, USP
DESCRIPTION
Amiloride HCl, an antikaliuretic-diuretic agent, is a
pyrazine-carbonyl-guanidine that is unrelated
chemically to other known antikaliuretic or diuretic agents. It is the
salt of a moderately strong base
(pKa 8.7). It is designated chemically as
3,5-diamino-6-chloro-_N_-(diaminomethylene)
pyrazinecarboxamide monohydrochloride, dihydrate and has a molecular
weight of 302.12. Its empirical
formula is C H ClN O•HCl•2H O and its structural formula is:
Amiloride HCl is available for oral use as tablets containing 5 mg of
anhydrous amiloride HCl. Each
tablet contains the following inactive ingredients: calcium phosphate,
lactose, magnesium stearate and
starch.
CLINICAL PHARMACOLOGY
Amiloride HCl is a potassium-conserving (antikaliuretic) drug that
possesses weak (compared with
thiazide diuretics) natriuretic, diuretic, and antihypertensive
activity. These effects have been partially
additive to the effects of thiazide diuretics in some clinical
studies. When administered with a thiazide
or loop diuretic, amiloride HCl has been shown to decrease the
enhanced urinary excretion of
magnesium which occurs when a thiazide or loop diuretic is used alone.
Amiloride HCl has potassium-
conserving activity in patients receiving kaliuretic-diuretic agents.
Amiloride HCl is not an aldosterone antagonist and its effects are
seen even in the absence of
aldosterone.
Amiloride HCl exerts its potassium sparing effect through the
inhibition of sodium reabsorption at the
distal convoluted tubule, cortical collecting tubule and collecting
duct; this decreases the net negative
potential of the tubular lumen and reduces both potassium and hydrogen
secretion and their subsequent
excretion. This mechanism accounts in large part for the potassium
sparing action of amiloride.
Amiloride HCl usually begins to act within 2 hours after an oral dose.
Its effect on electrolyte
excretion reaches a peak between 6 and 10