Država: Južnoafrička Republika
Jezik: engleski
Izvor: South African Health Products Regulatory Authority (SAHPRA)
Bayer
ADALAT® XL 30 ADALAT® XL 60 SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): ADALAT ® XL 30 ADALAT ® XL 60 (Controlled Release tablet) COMPOSITION: Each ADALAT XL 30 tablet contains 30 mg nifedipine Each ADALAT XL 60 tablet contains 60 mg nifedipine PHARMACOLOGICAL CLASSIFICATION: A 7.1. Vasodilators, hypotensive medicines. PHARMACOLOGICAL ACTION: Nifedipine, a calcium antagonist, improves oxygen supply to the myocardium with simultaneous decrease of oxygen requirements. Nifedipine has a vasodilatory effect on the peripheral arterial beds causing a fall in peripheral vascular resistance and an increase in peripheral blood flow. Ca 2+ -channel blockers are useful in low-renin hypertension. Nifedipine dilates submaximally both clear and atherosclerotic coronary arteries, thus protecting the heart against coronary artery spasm and improving perfusion to the ischaemic myocardium. ADALAT XL formulations release nifedipine at an approximately constant rate over 24 hours. The biologically inert components of the tablets remain intact during gastrointestinal transit and are eliminated in the faeces as an insoluble shell. INDICATIONS: Treatment of mild to moderate hypertension. Prophylaxis of chronic stable angina pectoris CONTRA-INDICATIONS: ADALAT XL may not be used at any time during pregnancy or lactation or in cases of hypersensitivity to nifedipine, nor must ADALAT XL be used in cardiovascular shock, clinically significant aortic stenosis, unstable angina, or during or within one month of a myocardial infarction. In single cases of in vitro fertilization, nifedipine has been associated with reversible biochemical changes in the spermatozoa's head section that may result in impaired sperm function. In men who are repeatedly unsuccessful in fathering a child by in vitro fertilizati Pročitajte cijeli dokument