WINAMOL Paracetamol Film-Coated Tablet 500mg

देश: मलेशिया

भाषा: अंग्रेज़ी

स्रोत: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

सक्रिय संघटक:

Paracetamol

थमां उपलब्ध:

KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.

INN (इंटरनेशनल नाम):

Paracetamol

पैकेज में यूनिट:

1 x 10tablet Tablets; 50tablet Tablets

द्वारा बनाया गया:

KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.

उत्पाद विशेषताएं

WINAMOL Paracetamol Film-Coated Tablet 500mg_ _
NAME AND STRENGTH OF ACTIVE SUBSTANCE:
Paracetamol………….. 500mg
Preservative:
Potassium Sorbate…….. 0.10% w/w
PRODUCT DESCRIPTION:
Pink colour film coated, circular biconvex tablet embossed with
“WINAMOL”.
PHARMACODYNAMICS:
Paracetamol is a centrally acting analgesic and antipyretic with
minimal anti-inflammatory properties.
Analgesic
The mechanism of analgesic action has not been fully determined.
Paracetamol may act predominantly
by inhibiting prostaglandin synthesis in the central nervous system
(specifically cyclooxygenase
(COX)-2) and, to a lesser extent, through a peripheral action by
blocking pain-impulse generation.
The peripheral action may also be due to inhibition of prostaglandin
synthesis or to inhibition of the
synthesis or actions of other substances that sensitize pain receptors
to mechanical or chemical
stimulation.
Antipyretic
Paracetamol
act
centrally
on
the
hypothalamic
heat-regulating
center
to
produce
peripheral
vasodilatation resulting in increase blood flow through the skin,
sweating and heat loss.
Paracetamol reduces fever by inhibiting the formulation and release of
prostaglandins in the CNS and
by inhibiting endogenous pyrogens at the hypothalamic thermoregulator
center.
PHARMACOKINETICS:
Following oral administration paracetamol is rapidly absorbed.
Paracetamol absorption takes place mainly in the small intestine and
therefore the rate of absorption is
depending on the rate of gastric emptying. It has been shown that
drugs which delay gastric emptying
also delay the absorption of paracetamol whereas metoclopramide (a
drug which increases the rate of
gastric emptying) accelerates absorption of the analgesic through the
total amount absorbed doses not
increase.
The presence of food in the stomach has also been reported to reduce
the rate of absorption of
paracetamol. Alterations in gastric pH have no appreciable effect on
paracetamol absorption.
During absorption, the amount of paracetamol which is inactivated is
negligiable