Vumon

देश: ऑस्ट्रेलिया

भाषा: अंग्रेज़ी

स्रोत: Department of Health (Therapeutic Goods Administration)

सक्रिय संघटक:

Teniposide

थमां उपलब्ध:

Bristol-Myers Squibb Australia Pty Ltd

वर्ग:

Medicine Registered

सूचना पत्रक

VUMON
®

_Teniposide (ten IP oh side)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Vumon
®
. It does not
contain all the available information.
It does not take the place of talking to
your doctor.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you being given Vumon
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR.
Keep this leaflet. You may need to
read it again.
WHAT VUMON IS USED
FOR
Vumon is used to treat types of
cancer known as Hodgkin's disease
and Non-Hodgkin's lymphoma. It
may also be used to treat leukaemia,
bladder cancer and brain cancer, as
well as some other forms of cancer.
Vumon belongs to a group of
medicines called cytotoxic
medicines. You may also hear of
these being called chemotherapy
medicines.
Vumon works by killing cancer cells.
Vumon may be used in combination
with other medicines to treat your
cancer.
Your doctor may have prescribed
Vumon for another reason. Ask your
doctor if you have any questions
about why Vumon has been
prescribed for you.
This medicine is available only with
a doctor's prescription.
BEFORE YOU ARE GIVEN
VUMON
_WHEN YOU MUST NOT BE GIVEN_
_IT_
DO NOT HAVE VUMON IF YOU HAVE AN
ALLERGY TO TENIPOSIDE,
POLYOXYETHYLATED CASTOR OIL OR ANY
OF THE OTHER INGREDIENTS LISTED AT
THE END OF THIS LEAFLET, UNLESS YOU
HAVE DISCUSSED IT WITH YOUR DOCTOR.
Symptoms of an allergic reaction
may include:
•
shortness of breath, wheezing,
difficulty breathing or a tight
feeling in your chest
•
swelling of the face, lips, tongue
or other parts of the body
•
rash, itching, hives or flushed, red
skin
•
dizziness or light headedness
•
fast heart beat
DO NOT HAVE VUMON IF YOU HAVE, OR
HAVE HAD, ANY OF THE FOLLOWING
MEDICAL CONDITIONS UNLESS YOU HAVE
DISCUSSED IT WITH YOUR DOCTOR:
•
low white blood cell count
•
low blood platelet count
•
low red blood cell count
•
liver problems
•
kidney problems
•

उत्पाद विशेषताएं

 
1

Vumon V5.0 1 November 2012 

PRODUCT INFORMATION 

VUMON
®

(TENIPOSIDE) 

NAME OF THE MEDICINE 

VUMON  (teniposide,  commonly  known  as  VM-26)  is  a  semisynthetic  derivative  of 
podophyllotoxin used in the treatment of certain
neoplastic diseases. 

It is 4'-0-demethyl-1-0(4,6-0-2
thenylidene-ß-D-glucopyranosyl) epipodophyllotoxin. 

STRUCTURAL FORMULA:  

Molecular weight 656.7 

Molecular formula C
32
H
32
0
13
S 

CAS number: 29767-20-2 

DESCRIPTION 

VUMON  a  neutral  lipophilic  compound  practically  insoluble  in  water.  It  must  be  prepared  in 
organic solvents. VUMON is administered by intravenous infusion. 

VUMON  Injection  is  available  as  a  faintly  yellow  solution  in  clear  glass  ampoules  containing 
50mg of teniposide dissolved in 5mL of an organic solution. Each mL of solution contains 10mg 
teniposide, 30mg benzyl alcohol, 60mg N,N-dimethylacetamide, 500mg polyoxyethylated castor 
oil, and ethanol with sufficient maleic acid to give a pH of 5. 

PHARMACOLOGY 

VUMON is a phase-specific cytotoxic drug, acting in the late S
2
 or G
2
 phase of the cell cycle by 
preventing  cells  from  entering  mitosis.  VUMON  also  produces  single-strand  breaks  in  DNA. 
The mechanism of action appears to be due to inhibition
of type II topoisomerases. 

Cells resistant to etoposide were fully cross resistant to teniposide and vice versa in both in vivo 
and  in  vitro  studies,  although  there  have  been  occasional  clinical  reports  suggesting  a  lack  of 
complete cross-resistance. 

2

Vumon V5.0 1 November 2012 
PHARMACOKINETICS 

ABSORPTION 
Absorption after oral administration is very variable in man, and
teniposide seems to be degraded 
partially in the gastrointes