TRIAMCINOLONE ACETONIDE paste

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

TRIAMCINOLONE ACETONIDE (UNII: F446C597KA) (TRIAMCINOLONE ACETONIDE - UNII:F446C597KA)

थमां उपलब्ध:

Cosette Pharmaceuticals, Inc.

INN (इंटरनेशनल नाम):

Triamcinolone Acetonide

रचना:

Triamcinolone Acetonide 1 mg in 1 g

प्रशासन का मार्ग:

DENTAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

चिकित्सीय संकेत:

Triamcinolone Acetonide Dental Paste, USP 0.1% is indicated for adjunctive treatment and for the temporary relief of symptoms associated with oral inflammatory lesions and ulcerative lesions resulting from trauma. Triamcinolone acetonide dental paste is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation; it is also contraindicated in the presence of fungal, viral, or bacterial infections of the mouth or throat.

उत्पाद समीक्षा:

Triamcinolone Acetonide Dental Paste, USP 0.1% is supplied in tubes containing 5 g of dental paste (NDC 0713-0655-40 ). Keep tightly closed. Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature]. Distributed by: Cosette Pharmaceuticals, Inc. South Plainfield, NJ 07080 Iss. 02/2021  8-0655CPLNC1   VC7479

प्राधिकरण का दर्जा:

Abbreviated New Drug Application

उत्पाद विशेषताएं

TRIAMCINOLONE ACETONIDE- TRIAMCINOLONE ACETONIDE PASTE
COSETTE PHARMACEUTICALS, INC.
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TRIAMCINOLONE ACETONIDE DENTAL PASTE, USP 0.1%
RX ONLY
DESCRIPTION
Triamcinolone Acetonide Dental Paste, USP 0.1%, contains the
corticosteroid
triamcinolone acetonide in an adhesive vehicle suitable for
application to oral tissues.
Triamcinolone acetonide is designated chemically as 9-fluoro-11β,
16α, 17, 21-
tetrahydroxypregna-1, 4-diene-3, 20-dione cyclic 16, 17-acetal with
acetone. The
structural formula of triamcinolone acetonide is as follows:
Each gram of triamcinolone acetonide dental paste contains 1 mg
triamcinolone
acetonide in an emollient dental paste containing gelatin, pectin, and
carboxymethylcellulose sodium in a plasticized hydrocarbon gel (a
polyethylene and
mineral oil gel base).
CLINICAL PHARMACOLOGY
Like other topical corticosteroids, triamcinolone acetonide has
anti-inflammatory,
antipruritic, and vasoconstrictive properties. The mechanism of the
anti-inflammatory
activity of the topical steroids, in general, is unclear. However,
corticosteroids are
thought to act by the induction of phospholipase A
inhibitory proteins, collectively
called lipocortins. It is postulated that these proteins control the
biosynthesis of potent
mediators of inflammation such as prostaglandins and leukotrienes by
inhibiting the
release of their common precursor, arachidonic acid. Arachidonic acid
is released from
membrane phospholipids by phospholipase A
.
PHARMACOKINETICS
2
2
The extent of absorption through the oral mucosa is determined by
multiple factors
including the vehicle, the integrity of the mucosal barrier, the
duration of therapy, and
the presence of inflammation and/or other disease processes. Once
absorbed through
the mucous membranes, the disposition of corticosteroids is similar to
that of
systemically administered corticosteroids. Corticosteroids are bound
to the plasma
proteins in varying degrees. Corticosteroids are metabolized primarily
in the liver and are
then excreted by the kidneys; some cortic