देश: मलेशिया
भाषा: अंग्रेज़ी
स्रोत: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
HYDROCORTISONE ACETATE
SUNWARD PHARMACEUTICAL SDN. BHD.
HYDROCORTISONE ACETATE
15gm mcg/mL; 15 gm Plastic mcg/mL; 500 gm; 400 gm; 450 gm; 30 gm Aluminium mcg/mL
SUNWARD PHARMACEUTICAL SDN. BHD.
PLEASE REFER TO COLUMN E12 पूरा दस्तावेज़ पढ़ें
Composition: Hydrocortisone Acetate 1.0% w/w PHARMACOLOGY: Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. However, there is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile. INDICATIONS: It is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. DOSAGE: A thin film of the cream is applied to be affected skin areas one to three times a day. Dosage of once or twice a day is often effective. SIDE-EFFECTS: The following local adverse reactions have been reported with topical dermatologic corticosteroids, especially under occlusive dressings; burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria. CONTRAINDICATIONS: It is contraindicated in patients who are hypersensitive to hydrocortisone or to any of the components of the preparation. PRECAUTION पूरा दस्तावेज़ पढ़ें