RIFAMPIN capsule, coated

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

RIFAMPIN (UNII: VJT6J7R4TR) (RIFAMPIN - UNII:VJT6J7R4TR)

थमां उपलब्ध:

Carilion Materials Management

INN (इंटरनेशनल नाम):

RIFAMPIN

रचना:

RIFAMPIN 300 mg

प्रशासन का मार्ग:

ORAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION DRUG

चिकित्सीय संकेत:

In the treatment of both tuberculosis and the meningococcal carrier state, the small number of resistant cells present within large populations of susceptible cells can rapidly become the predominant type. Bacteriologic cultures should be obtained before the start of therapy to confirm the susceptibility of the organism to rifampin and they should be repeated throughout therapy to monitor the response to treatment. Since resistance can emerge rapidly, susceptibility tests should be performed in the event of persistent positive cultures during the course of treatment. If test results show resistance to rifampin and the patient is not responding to therapy, the drug regimen should be modified. Rifampin is indicated in the treatment of all forms of tuberculosis. A three-drug regimen consisting of rifampin, isoniazid, and pyrazinamide (RIFATER manufactured by sanofi-aventis U.S. LLC) is recommended in the initial phase of short-course therapy which is usually continued for 2 months. The Advisory Council for the E

उत्पाद समीक्षा:

NDC:68151-0985-0 in a PACKAGE of 1 CAPSULE, COATEDS

प्राधिकरण का दर्जा:

Abbreviated New Drug Application

उत्पाद विशेषताएं

RIFAMPIN- RIFAMPIN CAPSULE, COATED
CARILION MATERIALS MANAGEMENT
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RIFAMPIN CAPSULES, USP
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of rifampin
capsules USP and other antibacterial drugs, rifampin should be used
only to treat or prevent infections
that are proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Rifampin capsules, USP contain 150 mg or 300 mg rifampin per capsule.
The 150 mg and 300 mg
capsules also contain, as inactive ingredients: colloidal silicon
dioxide, corn starch, FD&C Blue No. 1,
FD&C Red No. 40, gelatin, lactose monohydrate, magnesium stearate,
sodium lauryl sulfate, talc, and
titanium dioxide.
The printing ink contains ammonium hydroxide, isopropyl alcohol,
n-butyl alcohol, pharmaceutical
glaze, propylene glycol, simethicone, and titanium dioxide
Rifampin is a semisynthetic antibiotic derivative of rifamycin SV.
Rifampin is a red-brown crystalline
powder very slightly soluble in water at neutral pH, freely soluble in
chloroform, soluble in ethyl
acetate and in methanol. Its molecular weight is 822.95 and its
chemical formula is C H N O . The
chemical name for rifampin is either
3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin or
5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,20,22-heptamethyl-8-[N-(4-methyl-1-piper-
azinyl)formimidoyl]-2,7-(epoxypentadeca-[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione
21-
acetate. Its structural formula is:
CLINICAL PHARMACOLOGY
ORAL ADMINISTRATION
Rifampin is readily absorbed from the gastrointestinal tract. Peak
serum concentrations in healthy adults
and pediatric populations vary widely from individual to individual.
Following a single 600 mg oral
dose of rifampin in healthy adults, the peak serum concentration
averages 7 mcg/mL but may vary from 4
to 32 mcg/mL. Absorption of rifampin is reduced by about 30% when the
drug is ingested with food.
Rifampin is widely distributed throughout the body. It is present in
effective concentrations in many
organs and body fluids, in