देश: मलेशिया
भाषा: अंग्रेज़ी
स्रोत: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PIPERACILLIN SODIUM; TAZOBACTAM SODIUM
FRESENIUS KABI MALAYSIA SDN. BHD
PIPERACILLIN SODIUM; TAZOBACTAM SODIUM
50ml X 1vial Vials; 50ml X 10vial Vials; 50ml X 1vial Vials; 50ml X 5vial Vials
LABESFAL LABORATORIOS ALMIRO S.A.
PACKAGE INSERT - INSTRUCTIONS FOR USE - READ CAREFULLY! Piperacillin/Tazobactam Fresenius_ _Kabi 2 g/0.25 g powder for solution for infusion. Piperacillin/Tazobactam Fresenius_ _Kabi 4 g/0.5 g powder for solution for infusion. COMPOSITION Each vial contains 2 g of piperacillin (as sodium salt) and 0.25 g of tazobactam (as sodium salt). Each vial contains 4 g of piperacillin (as sodium salt) and 0.5 g of tazobactam (as sodium salt). Excipient: Glacial Acetic acid One vial of powder for solution for infusion contains 4.9 mmol (112 mg) of sodium One vial of powder for solution for infusion contains 9.7 mmol (224 mg) of sodium PHARMACEUTICAL FORM Powder for solution for infusion. White to off-white powder. PHARMACODYNAMICS Piperacillin, a broad spectrum, semisynthetic penicillin active against many Gram-positive and Gram-negative aerobic and anaerobic bacteria, exerts bactericidal activity by inhibition of both septum and cell wall synthesis. Tazobactam, a triazolmethyl penicillanic acid sulphone, is a potent inhibitor of many beta-lactamases, in particular the plasmid mediated enzymes which commonly cause resistance to penicillins and cephalosporins including the third generation cephalosporins. The presence of tazobactam in the piperacillin/tazobactam formulation enhances and extends the antibiotic spectrum of piperacillin to include many beta-lactamase producing bacteria normally resistant to it and other beta-lactam antibiotics. Thus piperacillin/tazobactam combines the properties of a broad spectrum antibiotic and a beta-lactamase inhibitor. Mechanism of resistance: The presence of tazobactam expands the spectrum of activity of piperacillin to include microorganisms that would otherwise, due to the formation of beta-lactamase, be resistant to piperacillin and other beta-lactam antibiotics. In vitro investigation has demonstrated that the type I beta-lactamase inducing ability of tazobactam is insignificant with regard to Gram-negative bacteria.ln vitro studies have demonstrated a synergetic effect of piperacilli पूरा दस्तावेज़ पढ़ें