देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
Rizatriptan benzoate
Merck Sharp & Dohme Australia Pty Ltd
Medicine Listed (Export Only)
MAXALT ® WAFERS _Rizatriptan benzoate_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET Please read this leaflet carefully before you start using MAXALT Wafers. This leaflet answers some common questions about MAXALT Wafers. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking MAXALT Wafers against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT MAXALT WAFERS ARE USED FOR MAXALT Wafers are used to relieve the headache pain and other symptoms of migraine attacks. MAXALT Wafers do not work for other types of headaches. Migraine is an intense, throbbing, typically one-sided headache. It often includes nausea, vomiting, sensitivity to light, and sensitivity to sound. Some people may have visual symptoms before the headache, called an aura. An aura can include flashing lights or wavy lines. Migraine attacks last anything from two hours to two days and they can return frequently. The severity and frequency of migraine attacks may vary. Migraine occurs in about one out of every 10 people. It is three times more common in women than men. Six out of ten migraine sufferers have their first attack before the age of 20. There is no single cause of migraine. It tends to run in families. Certain things, singly or in combination, can trigger migraine attacks in some people. Some of these triggers are: • certain foods or drinks, for example, cheese and other dairy products, chocolate, citrus fruit, caffeine, alcohol (especially red wine) • stress, anger, worry • changes in routine, for example, under or over sleeping, missing a meal, change in diet • bright light or loud noises • hormonal changes in women, for example, during menstrual periods If you understand what triggers your attacks, you पूरा दस्तावेज़ पढ़ें
MAXALT Wafer + Tablet PI A120508 v5 (0462-AUS-2012-004509) Page 1 PRODUCT INFORMATION MAXALT TABLETS / MAXALT WAFERS (RIZATRIPTAN BENZOATE, MSD) NAME OF THE MEDICINE Rizatriptan benzoate is described chemically as: _N,N_-dimethyl-5-(1_H_-1,2,4-triazol-1- ylmethyl)-1_H_-indole-3-ethanamine monobenzoate. Its empirical formula is C 15 H 19 N 5 •C 7 H 6 O 2 and its structural formula is: DESCRIPTION Rizatriptan benzoate is a white to off-white, crystalline solid. The molecular weight of the benzoate salt is 391.47; the molecular weight of the free base is 269.4. Rizatriptan benzoate is soluble in water at about 42 mg per mL (expressed as free base) at 25°C. Each compressed tablet contains either 7.265 mg or 14.53 mg of rizatriptan benzoate (corresponding to 5 mg or 10 mg of rizatriptan, respectively) and the following inactive ingredients: lactose, microcrystalline cellulose, pregelatinised maize starch, iron oxide red CI77491, and magnesium stearate. Each lyophilised wafer contains either 7.265 mg or 14.53 mg of rizatriptan benzoate (corresponding to 5 mg or 10 mg of rizatriptan, respectively) and the following inactive ingredients: gelatin, mannitol, glycine, aspartame, and peppermint flavour. PHARMACOLOGY MECHANISM OF ACTION_ _ Rizatriptan is a potent, orally active serotonergic agonist that has been shown in radioligand binding assays and functional pharmacological bioassays to act selectively at 5-HT 1B/1D receptors. Rizatriptan has no clinically significant activity at 5-HT 2 or 5-HT 3 receptor subtypes, nor at alpha- and beta-adrenergic, dopaminergic, histaminergic, muscarinic or benzodiazepine receptors._ _ Rizatriptan acts at craniovascular 5-HT 1B receptors to cause selective constriction of the extracerebral, intracranial arteries that are thought to be dilated during a पूरा दस्तावेज़ पढ़ें