MARQUIS ANTIPROTOZOAL- ponazuril paste

देश: संयुक्त राज्य

भाषा: अंग्रेज़ी

स्रोत: NLM (National Library of Medicine)

सक्रिय संघटक:

ponazuril (UNII: JPW84AS66U) (ponazuril - UNII:JPW84AS66U)

थमां उपलब्ध:

Merial, Inc.

INN (इंटरनेशनल नाम):

ponazuril

रचना:

ponazuril 150 mg in 1 g

प्रशासन का मार्ग:

ORAL

प्रिस्क्रिप्शन प्रकार:

PRESCRIPTION

चिकित्सीय संकेत:

INDICATIONS: MARQUIS is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona .

उत्पाद समीक्षा:

HOW SUPPLIED: Code: 84672831 Carton contains one (1) X 127 gram syringe applicator and one (1) reusable syringe plunger. Code: 84672866 Carton contains four (4) X 127 gram syringe applicators and four (4) reusable syringe plungers.

प्राधिकरण का दर्जा:

New Animal Drug Application

उत्पाद विशेषताएं

MARQUIS ANTIPROTOZOAL- PONAZURIL PASTE
MERIAL, INC.
----------
MARQUIS
(15% W/W PONAZURIL)
ANTIPROTOZOAL ORAL PASTE
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the
order of a licensed
veterinarian.
FOR THE TREATMENT OF EQUINE PROTOZOAL MYELOENCEPHALITIS (EPM) IN
HORSES
FOR ORAL USE ONLY
DESCRIPTION: MARQUIS (15% w/w ponazuril) Antiprotozoal Oral Paste is
supplied in
a ready-to-use syringe containing 127 grams of paste. Each gram of
paste contains 150
mg of ponazuril (15% w/w). MARQUIS is designed to be delivered as an
orally
administered paste.
Each syringe barrel of MARQUIS contains enough paste to treat one (1)
1,200 lb (544
kg) horse for seven (7) days, at a dose rate of 5 mg/kg (2.27 mg/lb)
body weight or to
treat one 1,200 lb (544 kg) horse with a single loading dose of 15
mg/kg (6.81 mg/lb)
body weight and for four days subsequently at a rate of 5 mg/kg (2.27
mg/lb) body
weight. The plunger contains a dosage ring calibrated for a dose rate
of 5 mg/kg (2.27
mg/lb) body weight and marked for horse weight from 600 to 1,200 lbs
(272 to 544 kg).
The syringe barrel is packaged with a reusable plunger. The syringe
barrels are
packaged in units of four with four reusable plungers and in single
syringe units with one
reusable plunger.
Ponazuril is an anticoccidial (antiprotozoal) compound with activity
against several
genera of the phylum Apicomplexa.
CHEMICAL NOMENCLATURE AND STRUCTURE: Ponazuril 1,3,5-Triazine-
2,4,6(1H,3H,5H)-trione,1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl]
phenoxy]phenyl]-(9Cl)
CLINICAL PHARMACOLOGY: The activity of ponazuril has been demonstrated
in
several Apicomplexans
. Lindsay, Dubey and Kennedy showed that the concentration
of ponazuril necessary to kill _Sarcocystis neurona in vitro_ was 0.1
to 1.0 μg/mL. Furr and
Kennedy evaluated the pharmacokinetics of ponazuril in serum and CSF
in normal
®
®
1-6
7
8
Kennedy evaluated the pharmacokinetics of ponazuril in serum and CSF
in normal
horses treated daily at 5 mg/kg for 28 days. The time to peak serum
conc