MAR-LISINOPRIL TABLET

देश: कनाडा

भाषा: अंग्रेज़ी

स्रोत: Health Canada

सक्रिय संघटक:

LISINOPRIL (LISINOPRIL DIHYDRATE)

थमां उपलब्ध:

MARCAN PHARMACEUTICALS INC

ए.टी.सी कोड:

C09AA03

INN (इंटरनेशनल नाम):

LISINOPRIL

डोज़:

10MG

फार्मास्यूटिकल फॉर्म:

TABLET

रचना:

LISINOPRIL (LISINOPRIL DIHYDRATE) 10MG

प्रशासन का मार्ग:

ORAL

पैकेज में यूनिट:

10/100/500/1000

प्रिस्क्रिप्शन प्रकार:

Prescription

चिकित्सीय क्षेत्र:

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

उत्पाद समीक्षा:

Active ingredient group (AIG) number: 0121550001; AHFS:

प्राधिकरण का दर्जा:

CANCELLED PRE MARKET

प्राधिकरण की तारीख:

2021-05-13

उत्पाद विशेषताएं

- 1 -
PRODUCT MONOGRAPH
PR
MAR-LISINOPRIL
(lisinopril tablets, USP)
Tablets 5mg, 10mg and 20 mg
Angiotensin Converting Enzyme Inhibitor
Marcan Pharmaceuticals Inc.
Date of Preparation:
77 Auriga Drive, Unit# 4
January 16, 2018
Ottawa, Ontario
K2E 7Z7
Control#: 212079
- 2 -
PRODUCT MONOGRAPH
PR
MAR-LISINOPRIL
(lisinopril tablets, USP)
Tablets 5mg, 10mg and 20 mg
Angiotensin Converting Enzyme Inhibitor
ACTIONS AND CLINICAL PHARMACOLOGY
MAR-LISINOPRIL (lisinopril) is an angiotensin converting enzyme (ACE)
inhibitor which is
used in the treatment of hypertension, congestive heart failure and
following myocardial infarction
in hemodynamically stable patients.
ACE is a peptidyl dipeptidase which catalyzes the conversion of
angiotensin I to the pressor
substance, angiotensin II. Inhibition of ACE results in decreased
plasma angiotensin II, which
leads to increased plasma renin activity (due to removal of negative
feedback of renin release) and
decreased aldosterone secretion. Although the latter decrease is
small, it results in a small increase
in serum potassium. In patients treated with lisinopril and a thiazide
diuretic there was essentially
no change in serum potassium (see PRECAUTIONS).
ACE is identical to kininase II. Thus, MAR-LISINOPRIL may also block
the degradation of
bradykinin, a potent vasodilator peptide. However, the role that this
plays in the therapeutic effects
of MAR-LISINOPRIL is unknown.
While the mechanism through which MAR-LISINOPRIL lowers blood pressure
is believed to be
primarily the suppression of the renin-angiotensin-aldosterone system
(RAAS), MAR-
LISINOPRIL also lowers blood pressure in patients with low-renin
hypertension.
PHARMACODYNAMICS
Hypertension:
_Adults:_
Administration of lisinopril to patients with hypertension results in
a reduction of both
supine and standing blood pressure. Abrupt withdrawal of lisinopril
has not been associated with a
rapid increase in blood pressure. In most patients studied, after oral
administration of an individual
dose of lisinopril, the onset of antihy