देश: दक्षिण अफ़्रीका
भाषा: अंग्रेज़ी
स्रोत: South African Health Products Regulatory Authority (SAHPRA)
Akromed
LORAMET® 0,5 mg capsule LORAMET® 1 mg capsule LORAMET® 2 mg capsule SCHEDULING STATUS: S5 PROPRIETARY NAME (and dosage form): LORAMET ® 0,5 mg capsule LORAMET ® 1 mg capsule LORAMET ® 2 mg capsule COMPOSITION: LORAMET 0,5 mg capsule contains 0,5 mg lormetazepam LORAMET 1 mg capsule contains 1 mg lormetazepam LORAMET 2 mg capsule contains 2 mg lormetazepam Lormetazepam is a 1,4-benzodiazepine and is chemically known as 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- 1-methyl-2H-1,4 benzodiazepine-2-one. Preservatives per capsule: sodium ethyl-p-hydroxybenzoate 0,08% and sodium propyl-p-hydroxybenzoate 0,04%. PHARMACOLOGICAL CLASSIFICATION: Category A, 2.2 Sedative, hypnotic. PHARMACOLOGICAL ACTION: LORAMET (lormetazepam) hastens the onset of sleep and increases total sleeping time. The exact mechanism of action of benzodiazepines has not yet been elucidated; however, benzodiazepines appear to work through several mechanisms. Benzodiazepines presumably exert their effects by binding to specific receptors at several sites within the central nervous system either by potentiating the effects of synaptic or presynaptic inhibition mediated by gamma-aminobutyric acid or directly affecting the action potential generating mechanisms. After oral administration LORAMET (lormetazepam) is rapidly and completely absorbed. Maximum plasma concentrations from the liquid filled soft gelatin capsules are reached within 60 minutes. The plasma elimination half-life is approximately 10 hours, but may range up to 12 hours. Elimination is mainly via the kidney. LORAMET (lormetazepam) has essentially a one-step metabolism. It is metabolised principally in the liver where most (94%) of the unchanged drug is directly conjugated to the glucuronide and excreted in this form. With oral dosing LORAMET (lormetazepam) underg पूरा दस्तावेज़ पढ़ें